N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
反应条件
pyridine in acetonitrile
参考文献
Griffin, Martin; Mongeot, Alexandre; Collighan, Russell; Saint, Robert E.; Jones, Richard A.; Coutts, Ian G.C.; Rathbone, Daniel L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5559 - 5562
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/67906 A2, 2007 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: 98 percent / K2CO3 / dimethylformamide / 20 °C 2: 46 percent / Candida antarctica lipase / aq. phosphate buffer / 38 h / 30 °C View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
dimethylsulfide borane complex
参考文献
Quintard, Adrien; Belot, Sebastien; Marchai, Estelle; Alexakis, Alexandre
European Journal of Organic Chemistry, 2010 , # 5 p. 927 - 936
反应条件
sodium hydroxide; sodium borohydride in tetrahydrofuran; methanol
参考文献
Abbott Laboratories
Patent: US5516912 A1, 1996 ;
反应条件
sodium borohydride; sodium hydrogencarbonate; acetic acid; lithium chloride in tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5122523 A1, 1992 ;
US 5122523 A
反应条件
4-(N,N-dimethlyamino)pyridine; TEA T=35°C; 0.5 h;
参考文献
Tetrahedron, , vol. 45, # 16 p. 5039 - 5050
反应条件
4-(N,N-dimethlyamino)pyridine in tert-butyl alcohol 0.916667 h; Ambient temperature;
参考文献
Synthesis, , # 10 p. 1063 - 1066
反应条件
pyridine; sodium carbonate in N-methyl-acetamide; acetonitrile
