N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
1: EDC; HOAt / dimethylformamide 2: H2 / Pd/C / methanol View Scheme
参考文献
Davies, Stephen J.; Ayscough, Andrew P.; Beckett, R. Paul; Clements, John M.; Doel, Sheila; Pratt, Lisa M.; Spavold, Zoe M.; Thomas, S. Wayne; Whittaker, Mark
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2715 - 2718
反应条件
1: 99 percent / thionyl chloride / CH2Cl2 / 1.) -10 deg C, 2 h, 2.) RT, overnight
2: 89 percent / tetrahydrofuran; diethyl ether / 1.) -20 deg C, 0.5 h, 2.) 0 deg C, 1 h
3: 86 percent / H2 / 5percent Pd/C / methanol / 3 h / Ambient temperature
4: 90 percent / CH2Cl2 / 48 h / Ambient temperature
5: 1.) sodium hydride, DMSO, triphenylmethane / 1.) RT, 2.) 10 min
6: 86 percent / 10percent KOH / 1.5 h / Heating
View Scheme
参考文献
Nakayama, Kensaku; Thompson, Wayne J.
Journal of the American Chemical Society, 1990 , vol. 112, # 19 p. 6936 - 6942
反应条件
1: 1.)isobutyl chloroformate, N-methylmorpholine; 2.)triethylamine / 1.) THF, -15 deg C, 5 min; 2.) THF, -15 deg C, 1h
2: t-butyl thiol / tetrahydrofuran / Ambient temperature; Irradiation
View Scheme
参考文献
Barton, Derek H. R.; Herve, Yolande; Potier, Pierre; Thierry, Josiane
Journal of the Chemical Society, Chemical Communications, 1984 , # 19 p. 1298 - 1299
反应条件
1: 1.) BH3
2: 88 percent
View Scheme
参考文献
Rueeger, Heinrich; Benn, Michael
Heterocycles, 1982 , vol. 19, # 9 p. 1677 - 1680
反应条件
1: Et3N / dimethylformamide / 0.25 h / -10 °C
2: dimethylformamide
3: H2, AcOH / Pd / methanol
View Scheme
参考文献
Yin, Guohui; Zhang, Richeng; Li, Lei; Tian, Jun; Chen, Ligong
European Journal of Organic Chemistry, 2013 , # 24 p. 5431 - 5438
反应条件
1: triethylamine; CHCl3 / anschliessend Behandeln mit N-Glycyl-glycin-aethylester
2: aqueous NaOH; aqueous acetone
3: methanol; palladium; aqueous acetic acid / Hydrogenation
View Scheme
参考文献
Davis; Smith
Journal of Biological Chemistry, 1953 , vol. 200, p. 373,383
反应条件
2-N-methylamino-1,3,2-dioxaphospholane in acetonitrile
T=30°C; 20 h;
参考文献
Kawanobe, Wataru; Yamaguchi, Kazuo; Nakahama, Seiichi; Yamazaki, Noboru
Chemistry Letters, 1982 , p. 825 - 828
反应条件
chloroform; triethylamine; isobutyl chloroformate
anschliessend Behandeln mit L-Leucin-<4-nitro-phenylester>-hydrobromid und Triaethylamin und nachfolgend mit Glycin-aethylester;
参考文献
Zaoral; Rudinger
Collection of Czechoslovak Chemical Communications, 1955 , vol. 20, p. 1183,1185
反应条件
1: triethylamine; isovaleryl chloride; toluene / Reagens 4: CHCl3: anschliessend Behandeln mit N-L-Leucyl-glycin-aethylester
2: aqueous acetone; aqueous NaOH
View Scheme
参考文献
Ressler; du Vigneaud
Journal of the American Chemical Society, 1954 , vol. 76, p. 3107
反应条件
1: 1) DCC / 1) CH2Cl2, 0 deg C, 30 min, 2) a) 0 deg C to r.t., b) r.t., overnight
2: H2 / 5percent Pd/C / methanol
3: LiAlH4 / tetrahydrofuran / 20 h / Heating
View Scheme
参考文献
Asami
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 3 p. 721 - 727
