N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
1: dicyclohexylcarbodiimide / tetrahydrofuran / 3 h / 0 °C
2: tetrahydrofuran / 1.) 3 h, 0 deg C; 2.) 12 h, r.t.
3: HBr / acetic acid / 0.17 h / Ambient temperature
4: N-ethylpiperidine / dimethylformamide / 12 h / Ambient temperature
View Scheme
参考文献
Hauzer, Karel; Servitova, Linda; Barth, Tomislav; Jost, Karel
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 4 p. 1139 - 1148
反应条件
dimethylaminopyidine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile
T=0°C; 2 h; 1) 0 deg C, 2 h 2) rt, 3 h;
参考文献
Ienaga, Kazuharu; Nakamura, Ko; Ishii, Akira; Taga, Tooru; Miwa, Yoshihisa; Yoneda, Fumio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1153 - 1156
反应条件
1: ethyl chloroformate, N-ethylpiperidine
2: 36percent HBr / acetic acid
View Scheme
参考文献
Kasafirek, Evzen; Fric, Premysl; Slaby, Jan; Kocna, Petr
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 12 p. 3034 - 3041
反应条件
1: dicyclohexylcarbodiimide / tetrahydrofuran / 3 h / 0 °C
2: tetrahydrofuran / 1.) 3 h, 0 deg C; 2.) 12 h, r.t.
View Scheme
参考文献
Hauzer, Karel; Servitova, Linda; Barth, Tomislav; Jost, Karel
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 4 p. 1139 - 1148
反应条件
chloroform; triethylamine; toluene
anschliessend Erwaermen mit <2>Naphthylamin;
参考文献
Folk; Burstone
Archives of Biochemistry, 1956 , vol. 61, p. 257,258
反应条件
sodium tetrahydroborate; ClOOEt; triethylamine in tetrahydrofuran
T=-10°C; 0.833333 h;
参考文献
Mori, Miwako; Washioka, Yumiko; Urayama, Takao; Yoshiura, Kagari; Chiba, Katsumi; Ban, Yoshio
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4058 - 4067
反应条件
1: 91 percent / EDCI; HOBT; NaHCO3 / CH2Cl2 / 24 h / 20 °C
2: 79 percent / H2 / Pd/C / methanol / 5 h / 1520 Torr
View Scheme
参考文献
Samanta, Sampak; Liu, Jinyun; Dodda, Rajasekhar; Zhao, Cong-Gui
Organic Letters, 2005 , vol. 7, # 23 p. 5321 - 5323
反应条件
1: SOCl2
2: 74 percent / NaOH / H2O; CH2Cl2 / 1 h
3: 74 percent / PPE / CH2Cl2 / 0.83 h / Heating
4: 90 percent / DDQ / benzene / Ambient temperature
5: 80 percent / NBS / CH2Cl2 / 0.75 h / Ambient temperature
View Scheme
参考文献
Hino, Tohru; Lai, Ziping; Seki, Hiroko; Hara, Ritsuko; Kuramochi, Tadao; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2596 - 2600
反应条件
1: SOCl2
2: 74 percent / NaOH / H2O; CH2Cl2 / 1 h
3: 74 percent / PPE / CH2Cl2 / 0.83 h / Heating
4: 90 percent / DDQ / benzene / Ambient temperature
View Scheme
参考文献
Hino, Tohru; Lai, Ziping; Seki, Hiroko; Hara, Ritsuko; Kuramochi, Tadao; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2596 - 2600
反应条件
1: SOCl2
2: 78 percent / NaOH / CH2Cl2; H2O / 0.42 h
3: 75 percent / PClO3 / benzene / 0.17 h / Heating
4: 55 percent / AlCl3, anisole / nitromethane / 3 h / Ambient temperature
5: 71 percent / NBS / CH2Cl2 / 0.5 h / Ambient temperature
6: 64 percent / BBr3 / CH2Cl2 / 5 h / Heating
View Scheme
参考文献
Hino, Tohru; Lai, Ziping; Seki, Hiroko; Hara, Ritsuko; Kuramochi, Tadao; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2596 - 2600
