N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
triethylamine in ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US3976635 A1, 1976 ;
参考文献
Goodman; Stueben
Journal of the American Chemical Society, 1959 , vol. 81, p. 3980,3982
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine 1.) CH2Cl2, 0 deg C, 10 min, 2.) 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Kim, Sunggak; Lee, Jae In; Kim, Youn Chul
Journal of Organic Chemistry, 1985 , vol. 50, # 5 p. 560 - 565
反应条件
ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran T=20°C; 24 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 1 p. 84 - 96
反应条件
tetrahydrofuran; chloroformic acid ethyl ester; triethylamine anschliessend Behandeln mit einer wss. Loesung von N-L-Leucyl-glycin-amid vom pH 10;
参考文献
Ivanov, A. K.; Antonov, A. A.; Donetskii, I. A.
Chemistry of Natural Compounds, 1992 , vol. 28, # 3/4 p. 344 - 349
Khimiya Prirodnykh Soedinenii, 1992 , # 3,4 p. 393 - 400
反应条件
α-chymotrypsin in water; N,N-dimethyl-formamide T=38°C; 2 h; pH 7, CaCl2;
参考文献
Cerovsky; Jost
Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 12 p. 2775 - 2782
反应条件
1: 63 percent / DCC / CH2Cl2 / 0 deg C to r.t. 2: H2 / 5percent Pd/C / methanol 3: LiAlH4 / tetrahydrofuran / 20 h / Heating View Scheme
参考文献
Clarke, Sarah L.; McSweeney, Christina M.; McGlacken, Gerard P.
Tetrahedron Asymmetry, 2014 , vol. 25, # 4 p. 356 - 361
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 24 h;
参考文献
Zhu, Ming-Kui; Cun, Lin-Feng; Mi, Ai-Qiao; Jiang, Yao-Zhong; Gong, Liu-Zhu
Tetrahedron Asymmetry, 2006 , vol. 17, # 4 p. 491 - 493
反应条件
thionyl chloride in tetrahydrofuran
参考文献
Dr. Karl Thomae GmbH
Patent: US4550107 A1, 1985 ;
US 4550107 A
反应条件
4-(N,N-dimethlyamino)pyridine in chloroform T=70°C; 4 h; Inert atmosphere;
参考文献
Bai, Jianfei; Zambron, Bartosz K.; Vogel, Pierre
Organic Letters, 2014 , vol. 16, # 2 p. 604 - 607
