N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
4-(N,N-dimethlyamino)pyridine; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane T=0 - 20°C;
参考文献
Liu, Jingyuan; West, Kevin R.; Bondy, Chantelle R.; Sanders, Jeremy K. M.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 5 p. 778 - 786
反应条件
1H-imidazole; dicyclohexyl-carbodiimide in ethyl acetate
参考文献
Pellicciari, Roberto; Garzon-Aburbeh, Aaron; Natalini, Benedetto; Marinozzi, Maura; Clerici, Carlo; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4201 - 4207
反应条件
in chloroform; ethyl acetate
参考文献
Ajinomoto Co., Inc.
Patent: US3933783 A1, 1976 ;
反应条件
1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / ethyl acetate / 0 - 20 °C 2.1: triethylamine / tetrahydrofuran / 20 °C 2.2: 48 h / 40 °C View Scheme
参考文献
Duan, Jianli; Sun, Yao; Chen, Hao; Qiu, Guofu; Zhou, Haibing; Tang, Ting; Deng, Zixin; Hong, Xuechuan
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7013 - 7022
反应条件
1: 80 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C 2: 76 percent / NaOH; HCl / acetone / 2 h 3: 95 percent / H2 / 10 percent Pd/C / H2O; methanol View Scheme
参考文献
Grassmann; Wuensch
Chemische Berichte, 1958 , vol. 91, p. 449,453
反应条件
1: 80 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C 2: 76 percent / NaOH; HCl / acetone / 2 h View Scheme
参考文献
Hashimoto; Tamaki; Sofuku; Muramatsu
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 5 p. 1533 - 1541
反应条件
1: N-methylmorpholine / CH2Cl2 / 2 h / -20 - -15 °C 2: NH3(gas) / CH2Cl2 / 1 h / -20 °C 3: H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr View Scheme
参考文献
Rispens, Minze T.; Gelling, Onko Jan; De Vries, Andre H.M.; Meetsma, Auke; Van Bolhuis, Fre; Feringa, Ben L.
Tetrahedron, 1996 , vol. 52, # 10 p. 3521 - 3546
反应条件
1: 35.9 g / boron trifluoride etherate / 1 h / Heating 2: 52.7 percent / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Corey, E.J.; Shibata, Saizo; Bakshi, Raman K.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2861 - 2863
反应条件
1: 60 percent / CH2Cl2 / 4 h / 20 °C 2: 50 percent / cyclohexene / Pd/C / methanol / 5 h / Heating 3: 52 percent / K2CO3 / ethane-1,2-diol / 5 h / Heating View Scheme
参考文献
Jhaumeer-Laulloo; Khodabocus; Jugoo; Jheengut; Sobha
Journal of the Indian Chemical Society, 2003 , vol. 80, # 8 p. 765 - 768
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=80°C; 0.0833333 h; Microwave irradiation;
参考文献
Vanier, Grace S.
Patent: US2007/209924 A1, 2007 ;
Location in patent: Page/Page column 7 ;
