N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
cell extract of Sphingomonas paucimobilis SC 16113 in water T=42°C; 20 h; Enzymatic reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 6-7 p. 830 - 834
反应条件
sulfuric acid in dichloromethane T=-8°C; 240 h;
参考文献
Mutulis, F. K.; Polis, Ya. Yu.; Raquel', B. P.; Sekatsis, I. P.; Mishnev, A. F.; Chipens, G. I.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 3.2 p. 501 - 506
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 3 p. 558 - 565
反应条件
1: With 4-methyl-morpholine in dichloromethane T=0°C; 0.166667 h; 2: With chloroformic acid ethyl ester in dichloromethane T=-15°C; 2 h; 3: With ammonia in dichloromethane T=-20 - 0°C; 1 h;
参考文献
Kalypsys, Inc.
Patent: US2006/116515 A1, 2006 ;
Location in patent: Page/Page column 66 ;
US 20060116515 A1
反应条件
1: H2SO4 / CH2Cl2 / 20 °C 2: H2 / 10 percent Pd-C / ethyl acetate / 20 °C / 760 Torr View Scheme
参考文献
Munegumi, Toratane; Fujita, Manabu; Maruyama, Tetsuya; Shiono, Shozo; Takasaki, Michiaki; Harada, Kaoru
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 1 p. 249 - 254
反应条件
1: 96 percent / di-tert-butyl dicarbonate; NH4HCO3; pyridine / acetonitrile / 5 h / 20 °C 2: 97 percent / cyanuric chloride / dimethylformamide / 4 h / 0 - 20 °C 3: triethylamine hydrochloride; sodium azide / toluene / 24 h / 95 °C 4: 1.50 g / hydrogen / Pd/C / ethyl acetate; acetic acid; ethanol / 80 °C / 750.06 Torr View Scheme
参考文献
Cobb, Alexander J. A.; Shaw, David M.; Longbottom, Deborah A.; Gold, Johan B.; Ley, Steven V.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 1 p. 84 - 96
反应条件
1: 1.) N,N-dimethylchloromethyleniminium chloride; 2.) 2.00 M sodium borohydride / 1.) acetonitrile, THF, -30 deg C, 1 h; 2.) acetonitrile, THF, N,N-dimethylformamide, -78 deg C to -20 deg C, 2 h 2: H2 / Pd/C View Scheme
参考文献
Fujisawa, Tamotsu; Mori, Toshiki; Sato, Toshio
Chemistry Letters, 1983 , p. 835 - 838
反应条件
trifluoroacetic anhydride in acetonitrile T=80°C; 5 h; Yields of byproduct given;
参考文献
Kawase, Masami; Hirabayashi, Michitaka; Koiwai, Hiromi; Yamamoto, Katsumi; Miyamae, Hiroshi
Chemical Communications, 1998 , # 6 p. 641 - 642
反应条件
trifluoroacetic anhydride T=80°C; 5 h; Yields of byproduct given;
参考文献
Kawase, Masami; Hirabayashi, Michitaka; Koiwai, Hiromi; Yamamoto, Katsumi; Miyamae, Hiroshi
Chemical Communications, 1998 , # 6 p. 641 - 642
反应条件
1: 1.) N-methylmorpholine, EtOCOCl 2: 90 percent / H2 / 10percent Pd/C / methanol / 5 h / Ambient temperature 3: 78 percent / LiAlH4 / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Mukaiyama, Teruaki
Tetrahedron, 1981 , vol. 37, # 23 p. 4111 - 4119
反应条件
1: 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / CH2Cl2; tetrahydrofuran / 4 h 2: 397 mg / AcOH / 1.5 h / 65 °C 3: H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr View Scheme
参考文献
Joyeau, Roger; Maoulida, Chanfi; Guillet, Cindy; Frappier, Francois; Teixeira, Antonio R.L.; Schrevel, Joseph; Santana, Jaime; Grellier, Philippe
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 2 p. 257 - 266
