N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
1: 98 percent / K2CO3 / dimethylformamide / 20 °C 2: 46 percent / Candida antarctica lipase / aq. phosphate buffer / 38 h / 30 °C 3: 97 percent / NaBH4; LiCl View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
cell extract of Sphingomonas paucimobilis SC 16113 in water T=42°C; 20 h; Enzymatic reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 6-7 p. 830 - 834
反应条件
thionyl chloride rt., 1 h, then reflux, 2 h;
参考文献
Pfeifer, Marc E.; Linden, Anthony; Robinson, John A.
Helvetica Chimica Acta, 1997 , vol. 80, # 5 p. 1513 - 1527
反应条件
1: oxalylchloride, DMF / benzene / 3 h 2: benzene / 1 h View Scheme
参考文献
Kurokawa, Masayuki; Shindo, Takeyuki; Suzuki, Masumi; Nakajima, Nobuyoshi; Ishihara, Kohji; Sugai, Takeshi
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1323 - 1333
反应条件
in methanol; benzene
参考文献
Hayashi, Yujiro; Matsuzawa, Masayoshi; Yamaguchi, Junichiro; Yonehara, Sayaka; Matsumoto, Yasunobu; Shoji, Mitsuru; Hashizume, Daisuke; Koshino, Hiroyuki
Angewandte Chemie - International Edition, 2006 , vol. 45, # 28 p. 4593 - 4597
参考文献
Shibuya, Masatoshi; Sato, Takahisa; Tomizawa, Masaki; Iwabuchi, Yoshiharu
Chemical Communications, 2009 , # 13 p. 1739 - 1741
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran 0.0833333 h; Ambient temperaturevar. reag., Et3N, var. time and solv.; Product distribution;
参考文献
Takeda; Akiyama; Nakamura; Takizawa; Mizuno; Takayanagi; Harigaya
Synthesis, 1994 , # 10 p. 1063 - 1066
参考文献
Gardiner, John M.; Bruce, Sarah E.
Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1029 - 1032
反应条件
1: N-methylmorpholine, ethyl chloroformate / ethyl acetate / -15 degC, 1 h and 0 degC, 1 h 2: H2 / Pd-C / methanol / 3 h 3: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Mukaiyama, Teruaki
Tetrahedron, 1981 , vol. 37, # 23 p. 4111 - 4119
反应条件
1: N-methylmorpholine / CH2Cl2 / 2 h / -20 - -15 °C 2: NH3(gas) / CH2Cl2 / 1 h / -20 °C 3: 87 percent / H2 / 5percent Pd/C / methanol / 5 h / 2068.6 Torr View Scheme
参考文献
Tetrahedron, , vol. 52, # 10 p. 3521 - 3546
