2,2-二氟-1-(4-甲氧基苯基)乙酮合成路线 （共 9 条）
反应条件
4 A molecular sieve; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=-10°C; 8 h;
参考文献
Peng, Weimin; Shreeve, Jean'ne M.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5760 - 5763
反应条件
aluminium trichloride in dichloromethane
T=8 - 20°C;
参考文献
Kolycheva, M. T.; Yagupol'skii, Yu. L.; Zaitsev, L. M.; Gerus, I. J.; Kukhar', V. P.; Klebanov, B. M.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 110 - 114
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 159 - 163
反应条件
1: flash-vacuum pyrolysis;
2: With water
参考文献
Boonkitpattarakul, Kanhokthron; Soorukram, Darunee; Tuchinda, Patoomratana; Reutrakul, Vichai; Pohmakotr, Manat
Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 987 - 990
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
反应条件
1: CF3CO2H / cyclohexane / Heating
2: 1-Cl2CH-4-F-1,4-diazoniabicyclo[2.2.2]octane bis(BF4) / acetonitrile / 4 h / 80 °C
3: aq. HCl / acetonitrile / 0.17 h
View Scheme
参考文献
Pravst, Igor; Zupan, Marko; Stavber, Stojan
Synthesis, 2005 , # 18 art. no. T07205SS, p. 3140 - 3146
反应条件
hydrogenchloride; sodium carbonate; N-fluorobislt;(trifluoromethyl)sulfonylgt;imide
1.) CH2Cl2, room temp., 5 h, 2.) CH2Cl2; Yield given. Multistep reaction;
参考文献
Ying; DesMarteau; Gotoh
Tetrahedron, 1996 , vol. 52, # 1 p. 15 - 22
反应条件
hydrogenchloride; sodium carbonate; N-fluorobislt;(trifluoromethyl)sulfonylgt;imide
1.) CH2Cl2, room temp., 5 h, 2.) CH2Cl2; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ying; DesMarteau; Gotoh
Tetrahedron, 1996 , vol. 52, # 1 p. 15 - 22
反应条件
1: With methanol; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate)
1 h; Microwave irradiation;
2: With water
0.25 h; Microwave irradiation;
参考文献
Krane Thvedt, Thor Hakon; Fuglseth, Erik; Sundby, Eirik; Hoff, Bard Helge
Tetrahedron, 2009 , vol. 65, # 46 p. 9550 - 9556
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate)
1 h; Microwave irradiation;
参考文献
Krane Thvedt, Thor Hakon; Fuglseth, Erik; Sundby, Eirik; Hoff, Bard Helge
Tetrahedron, 2009 , vol. 65, # 46 p. 9550 - 9556
