1: 2-bromo-α-(ethenyl)benzenemethanol With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: With n-butyllithium in tetrahydrofuran
T=-70°C; 1 h;
3: tri-isopropoxy-borane
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; WANG, Tiansheng; HANZELKA, Brian; MUH, Ute; BEMIS, Guy; ZUCCOLA, Harmon, J.
Patent: WO2011/19405 A1, 2011 ;
Location in patent: Page/Page column 208 ;
WO 2011/019405 A1
