1-(2-氯-4-硝基苯基)哌嗪合成路线 （共 6 条）
反应条件
in N,N-dimethyl-formamide T=20 - 100°C;
参考文献
The University of Hong Kong
Patent: US2011/212975 A1, 2011 ;
Location in patent: Page/Page column 13; 18 ;
反应条件
pyridine in 1,4-dioxane T=0 - 20°C;
参考文献
VIRONOVA AB; HOMMAN, Mohammed; KINGI, Ngarita; BERGMAN, Jan; ENGQVIST, Robert
Patent: WO2013/171334 A1, 2013 ;
Location in patent: Page/Page column 23 ;
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 2 h;
参考文献
The University of Hong Kong
Patent: US2011/212975 A1, 2011 ;
Location in patent: Page/Page column 14; 18 ;
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 4 h;
参考文献
WO2011/15037 A1, ;
Page/Page column 42; 54-55 ;
反应条件
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
THE UNIVERSITY OF HONGKONG; KAO, Yitsun, Richard; YANG, Dan; YEUN, Kwokyung
Patent: WO2011/15037 A1, 2011 ;
Title/Abstract Full Text Show Details
The University of Hong Kong
Patent: US2011/212975 A1, 2011 ;
