2-氟-4-溴苯乙腈合成路线

GLAXOSMITHKLINE LLC; GHERGUROVICH, Jonathan, Michael; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; RIDGERS, Lance, Howard; YU, Hongyi
Patent: WO2013/28447 A1, 2013 ;
Location in patent: Page/Page column 93-94 ;

114897-91-52-氟-4-溴苯乙腈+

74-88-4甲基碘

193290-19-6(4-溴-2-氟苯基)乙酸甲酯

参考文献

SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 165-166 ;

114897-91-52-氟-4-溴苯乙腈

114897-92-64-溴-2-氟苯乙酸

参考文献

J. Uriach and Cia, S.A.
Patent: US5827863 A1, 1998 ;
US 5827863 A

114897-91-52-氟-4-溴苯乙腈+

74-88-4甲基碘

749928-77-62-(4-溴-2-氟苯基)-2-甲基丙腈

参考文献

PFIZER INC.
Patent: WO2006/18725 A1, 2006 ;
Location in patent: Page/Page column 172 ;
WO 2006/018725 A1

114897-91-52-氟-4-溴苯乙腈+

80-48-8对甲苯磺酸甲酯

749928-77-62-(4-溴-2-氟苯基)-2-甲基丙腈

参考文献

Camp, David; Matthews, Chris F.; Neville, Sean T.; Rouns, Michael; Scott, Robert W.; Truong, Yen
Organic Process Research and Development, 2006 , vol. 10, # 4 p. 814 - 821

114897-91-52-氟-4-溴苯乙腈+

107-04-01-溴-2-氯乙烷

749928-88-9

参考文献

Daiichi Sankyo Company, Limited; MORI, Makoto; FUJII, Kunihiko; INUI, Masaharu; BABA, Takayuki; ONISHI, Yukari; AOYAGI, Atsushi
Patent: EP2700643 A1, 2014 ;
Location in patent: Paragraph 0189 ;

114897-91-52-氟-4-溴苯乙腈+

106-93-4二溴乙烷

749928-88-9

参考文献

F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao
Patent: WO2013/189865 A1, 2013 ;
Location in patent: Page/Page column 53-54 ;