反应条件
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / |Inert atmosphere; |Cooling with ice
1.2: 3 h / 20 °C / |Inert atmosphere; |Cooling with ice
2.1: water; lithium hydroxide hydrate / 100 °C
View Scheme
参考文献
Daiichi Sankyo Company, Limited; MORI, Makoto; FUJII, Kunihiko; INUI, Masaharu; BABA, Takayuki; ONISHI, Yukari; AOYAGI, Atsushi
Patent: EP2700643 A1, 2014 ;