2,6-二甲基吡啶-3,5-二甲酸二乙酯合成路线 （共 142 条）
反应条件
1.1: potassium hydroxide / ethanol / 1 h / |Reflux 2.1: potassium permanganate / water / 1.5 h / |Reflux 2.2: pH 1 3.1: sulfuric acid / 12 h / 0 °C / |Reflux 4.1: ammonia; ammonium chloride / water / 12 h / 20 °C 5.1: thionyl chloride / N,N-dimethyl-formamide / 14 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Woess, Eva; Monkowius, Uwe; Knoer, Guenther
Chemistry - A European Journal, 2013 , vol. 19, # 4 p. 1489 - 1495
反应条件
hydrazine hydrate 6 h; RefluxNeat (no solvent);
参考文献
Wang, Xiayun; Zhu, Yiwen; Zhang, Min; Lu, Dongliang; Qian, Qun; Chen, Yali; Cao, Weiguo; Song, Liping; Deng, Hongmei
Chinese Journal of Chemistry, 2011 , vol. 29, # 10 p. 2119 - 2123
反应条件
palladium beim Erhitzen im Kohlendioxydstrom;
参考文献
Knoevenagel; Fuchs
Chemische Berichte, 1903 , vol. 36, p. 2857
反应条件
1: lithium alanate; diethyl ether
2: thionyl chloride
3: palladium/calcium carbonate; methanol / Hydrogenation
View Scheme
参考文献
Tsuda et al.
Pharmaceutical Bulletin, 1953 , vol. 1, p. 122,125
参考文献
Mohr; Schneider
Journal fuer Praktische Chemie (Leipzig), 1904 , vol. <2> 69, p. 247,248
Full Text Show Details
Engelmann
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 38
反应条件
1: 1.) LiAlH4, sodium sulfate / 1.) THF, 0 deg C, 15 min; 2.) reflux, 12 h, THF
2: 95 percent / thionyl chloride / 2 h / Ambient temperature
View Scheme
参考文献
Kang, Hee Chol; Boekelheide, Virgil
Angewandte Chemie, 1981 , vol. 93, # 6/7 p. 587
反应条件
sodium ethanolate in ethanol
2 h; Heating;
参考文献
Balogh; Hermecz; Simon; Pusztay
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 6 p. 1755 - 1769
反应条件
1: 50.7 percent / 1.) 140 deg C, 6 h; 2.) 4 deg C, 2 d;
2: 64.3 percent / 25 percent aq. ammonium hydroxide / ethanol / 36 h / Ambient temperature
View Scheme
参考文献
Balogh, Maria; Hermecz, Istvan; Naray-Szabo, Gabor; Simon, Kalman; Meszaros, Zoltan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 753 - 758
反应条件
1: hydrazine hydrate
2: hydrochloric acid; sodium nitrite / 0 - 5 °C
View Scheme
参考文献
Mohr
Chemische Berichte, 1900 , vol. 33, p. 1115
反应条件
1: hydrazine hydrate / 6 h / Reflux; Neat (no solvent)
2: toluene-4-sulfonic acid / chloroform / 2 h / Reflux
3: acetic acid / toluene / 1.5 h / Reflux
View Scheme
参考文献
Wang, Xiayun; Zhu, Yiwen; Zhang, Min; Lu, Dongliang; Qian, Qun; Chen, Yali; Cao, Weiguo; Song, Liping; Deng, Hongmei
Chinese Journal of Chemistry, 2011 , vol. 29, # 10 p. 2119 - 2123
