(2R,3S,5S)-5-(4-氨基吡咯并[3,2-c]吡啶-1-基)-2-(羟基甲基)四氢呋喃-3-醇合成路线 （共 6 条）
反应条件
ammonia; hydrogen; palladium on activated charcoal in methanol 30 h; Ambient temperature;
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
1: 80 percent / NH3 / methanol / 24 h / Ambient temperature 2: 1) N2H4*H2O, 2) Raney nickel / 1) reflux, 1.5 h, 2) water, reflux, 45 min View Scheme
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
1: 90 percent / KOH, cryptand TDA-1 / acetonitrile / 0.75 h / Ambient temperature 2: 72 percent / NH3 / methanol / 12 h / 50 °C 3: N2H4 / 1 h / 80 °C 4: Raney nickel / ethanol / 2 h / Heating 5: 40 percent / NH3, H2 / 10percent Pd/C / methanol / 30 h / Ambient temperature View Scheme
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
1: N2H4 / 1 h / 80 °C 2: Raney nickel / ethanol / 2 h / Heating 3: 40 percent / NH3, H2 / 10percent Pd/C / methanol / 30 h / Ambient temperature View Scheme
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
1: 90 percent / KOH, cryptand TDA-1 / acetonitrile / 0.75 h / Ambient temperature 2: 72 percent / NH3 / methanol / 12 h / 50 °C 3: N2H4 / 1 h / 80 °C 4: Raney nickel / ethanol / 2 h / Heating 5: 40 percent / NH3, H2 / 10percent Pd/C / methanol / 30 h / Ambient temperature View Scheme
参考文献
Seela; Bourgeois
Synthesis, 1988 , # 12 p. 938 - 943
反应条件
nickel; hydrazine hydrate 1) reflux, 1.5 h, 2) water, reflux, 45 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Cristalli, Gloria; Franchetti, Palmarisa; Grifantini, Mario; Nocentini, Giuseppe; Vittori, Sauro
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1463 - 1466
