N-去-t-叔丁氧羰基-10-去乙酰基-7,10-O-二{[(2,2,2-三氯乙基)氧基]羰基}多西他赛合成路线 （共 15 条）
反应条件
formic acid T=20°C; 4 h;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
trimethylsilyl iodide in acetonitrile T=0°C; 0.5 h;
参考文献
Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier
Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190
反应条件
1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 2: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 4: 100 percent / LiOH, H2O / ethanol / 20 °C 5: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 6: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 1.) Et3N, Bu2BOTf / 1.) CH2Cl2, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h 2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C 3: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 4: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 5: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 6: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 7: 100 percent / LiOH, H2O / ethanol / 20 °C 8: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 9: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 2: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 3: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 4: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 5: 100 percent / LiOH, H2O / ethanol / 20 °C 6: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 7: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C 2: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 3: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 4: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 5: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 6: 100 percent / LiOH, H2O / ethanol / 20 °C 7: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 8: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Chang, Jun; Hao, Xiao-Dong; Hao, Yun-Peng; Lu, Hong-Fu; Yu, Jian-Ming; Sun, Xun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6834 - 6837
反应条件
1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 3: 100 percent / LiOH, H2O / ethanol / 20 °C 4: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 5: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 2: 100 percent / LiOH, H2O / ethanol / 20 °C 3: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 4: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
