N-去-t-叔丁氧羰基-10-去乙酰基-7,10-O-二{[(2,2,2-三氯乙基)氧基]羰基}多西他赛合成路线 (共 15 条)
反应条件
1: 100 percent / LiOH, H2O / ethanol / 20 °C 2: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 3: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: pyridine / 0.5 h / 20 °C 2: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / toluene 3: formic acid / 2 h / 20 °C View Scheme
参考文献
Chang, Jun; Hao, Xiao-Dong; Hao, Yun-Peng; Lu, Hong-Fu; Yu, Jian-Ming; Sun, Xun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6834 - 6837
反应条件
1: pyridine / 3 h / Ambient temperature 2: 90 percent / Zn, AcOH / methanol / 2 h / 60 °C View Scheme
参考文献
Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier
Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190
反应条件
sodium hydrogencarbonate in tetrahydrofuran T=20°C;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C 2: 90 percent / Zn, HOAc / methanol / 1 h / 60 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188