4-(6-氨基嘌呤-9-基)丁-2,3-二烯-1-醇合成路线 （共 8 条）
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=-10°C; 1.5 h;
参考文献
Phadtare, Shashikant; Zemlicka, Jiri
Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931
反应条件
ammonia in methanol 1.5 h; Ambient temperature;
参考文献
Megati, Sreenivasulu; Goren, Zafrir; Silverton, James V.; Orlina, Joel; Nishimura, Hisao; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4098 - 4104
反应条件
sodium hydroxide in 1,4-dioxane 1 h; Heating;
参考文献
Phadtare, Shashikant; Zemlicka, Jiri
Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931
反应条件
1: 68 percent / aq. HCl / 18 h / Heating 2: 50 percent / t-BuOK / dimethylformamide / 1.5 h / -10 °C View Scheme
参考文献
Phadtare, Shashikant; Zemlicka, Jiri
Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931
反应条件
1: 53 percent / K2CO3 / dimethylsulfoxide / 18 h / Ambient temperature 2: 68 percent / aq. HCl / 18 h / Heating 3: 50 percent / t-BuOK / dimethylformamide / 1.5 h / -10 °C View Scheme
参考文献
Phadtare, Shashikant; Zemlicka, Jiri
Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931
参考文献
Megati, Sreenivasulu; Goren, Zafrir; Silverton, James V.; Orlina, Joel; Nishimura, Hisao; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4098 - 4104
反应条件
triethylamine in dichloromethane Ambient temperature;
参考文献
Megati; Phadtare; Zemlicka
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2320 - 2327
反应条件
tetrachloromethane; triphenylphosphine in N,N-dimethyl-formamide 15 h; Ambient temperature;
参考文献
Phadtare, Shashikant; Zemlicka, Jiri
Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931
