2-甲基-3-丁烯-2-醇合成路线 （共 471 条）
反应条件
1.1: 49 percent / formic acid; H2O / 0.33 h / 80 °C
2.1: polystyrene-based selenenyl bromide resin / CH2Cl2 / 0.33 h / 0 - 25 °C
2.2: H2O2 / tetrahydrofuran / 0.33 h / 25 °C
View Scheme
参考文献
Nicolaou; Pfefferkorn; Roecker; Cao; Barluenga; Mitchell
Journal of the American Chemical Society, 2000 , vol. 122, # 41 p. 9939 - 9953
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
T=20°C; 1 h; Inert atmosphere;
参考文献
Tadigoppula, Narender; Korthikunta, Venkateswarlu; Gupta, Shweta; Kancharla, Papireddy; Khaliq, Tanvir; Soni, Awakash; Srivastava, Rajeev Kumar; Srivastava, Kumkum; Puri, Sunil Kumar; Raju, Kanumuri Siva Rama; Wahajuddin; Sijwali, Puran Singh; Kumar, Vikash; Mohammad, Imran Siddiqi
Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 31 - 45
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
T=50°C; 2 h; Inert atmosphere;
参考文献
Grealis, John P.; Mueller-Bunz, Helge; Ortin, Yannick; Casey, Michael; McGlinchey, Michael J.
European Journal of Organic Chemistry, 2013 , # 2 p. 332 - 347
反应条件
1: 65 percent / aq. HCOOH / 4 h / Heating
2: 60 percent / AlCl3 / CH2Cl2 / 2 h / -10 - 20 °C
3: 95 percent / DDQ / benzene / 4 h / Heating
View Scheme
参考文献
Harel, Dipak; Khalid, Sami A.; Kaiser, Marcel; Brun, Reto; Wuensch, Bernhard; Schmidt, Thomas J.
Journal of Ethnopharmacology, 2011 , vol. 137, # 1 p. 620 - 625
参考文献
National Distillers and Chemical Corporation
Patent: US4968817 A1, 1990 ;
反应条件
in N,N-dimethyl-formamide
electrolyses;
参考文献
Dapremont, Christine; Cals, Patrick; Commeyras, A.; Amatore, Christian
Journal of Fluorine Chemistry, 1992 , vol. 56, # 2 p. 249 - 258
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 36 h / 20 °C / |Inert atmosphere
2.1: bis(dibenzylideneacetone)-palladium(0) / 0.08 h / |Inert atmosphere; |Sealed tube
2.2: 24 h / 50 °C / |Inert atmosphere; |Sealed tube
3.1: potassium hydrogen difluoride / acetone; water / 2 h / 20 °C / |Inert atmosphere
4.1: montmorrolonite K10 / water; dichloromethane / 16 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Beveridge, Ramsay E.; Batey, Robert A.
Organic Letters, 2014 , vol. 16, # 9 p. 2322 - 2325
反应条件
toluene-4-sulfonic acid in benzene
参考文献
Kuznetsov,N.V.; Svishchuk,A.A.
Sov. Prog. Chem. (Engl. Transl.), 1966 , vol. 32, p. 725 - 727,559 - 560
反应条件
1.1: 96.3 percent / aq. HCl / 1 h / 0 °C
2.1: 96.4 percent / TEBA / 4.5 h / 95 - 105 °C
3.1: 95 percent / aq. NaOH / 2.5 h / 100 °C
4.1: 95 percent / MnO2 / petroleum ether / 7 h / 20 °C
5.1: LiCl; hydroquinone / toluene / Heating
5.2: LiCl / various solvent(s) / 135 °C
View Scheme
参考文献
Vani; Chida; Srinivasan; Chandrasekharam; Singh
Synthetic Communications, 2001 , vol. 31, # 2 p. 219 - 224
反应条件
triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; palladium diacetate in hexane; water
T=20°C; 24 h;
参考文献
Komine, Nobuyuki; Sako, Akari; Hirahara, Shin-Ya; Hirano, Masafumi; Komiya, Sanshiro
Chemistry Letters, 2005 , vol. 34, # 2 p. 246 - 247
