2-甲基-3-丁烯-2-醇合成路线 （共 471 条）
反应条件
sodium hydride; 1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride in tetrahydrofuran
T=65°C; 36 h; further Ni catalysts; Product distribution;
参考文献
Alvarez, Eleuterio; Cuvigny, Therese; Julia, Marc
Journal of Organometallic Chemistry, 1988 , vol. 339, p. 199 - 212
反应条件
toluene-4-sulfonic acid in toluene
T=100°C; 18 h; Title compound not separated from byproducts.;
参考文献
Hong, Mei Peng; Webster, Richard D.
Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2169 - 2175
反应条件
1: 70 percent / H2SO4 / diisopropyl ether / 3 h / 55 - 58 °C
2: 60 percent / AcOH; AcOOH / H2O / 22 °C
3: 97 percent / MeONa; MeOH / 0.25 h / 22 °C
View Scheme
参考文献
Patel, Anjan; Liebner, Falk; Netscher, Thomas; Mereiter, Kurt; Rosenau, Thomas
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6504 - 6512
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
T=20°C; 1 h;
参考文献
TAKARA BIO INC.
Patent: EP1623704 A1, 2006 ;
Location in patent: Page/Page column 58 ;
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
T=20°C; 1 h; Inert atmosphere;
参考文献
Tadigoppula, Narender; Korthikunta, Venkateswarlu; Gupta, Shweta; Kancharla, Papireddy; Khaliq, Tanvir; Soni, Awakash; Srivastava, Rajeev Kumar; Srivastava, Kumkum; Puri, Sunil Kumar; Raju, Kanumuri Siva Rama; Wahajuddin; Sijwali, Puran Singh; Kumar, Vikash; Mohammad, Imran Siddiqi
Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 31 - 45
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
T=50°C; 2 h; Inert atmosphere;
参考文献
Grealis, John P.; Mueller-Bunz, Helge; Ortin, Yannick; Casey, Michael; McGlinchey, Michael J.
European Journal of Organic Chemistry, 2013 , # 2 p. 332 - 347
反应条件
1: 0.2 g / BF3.Et2O / dioxane / 1 h / 35 - 40 °C
2: 0.5 g / Zn/cc. HCl / ethanol / 0.5 h / Heating
View Scheme
参考文献
Ahluwalia, V. K.; Prakash, Chandra; Gupta, Ranjna
Tetrahedron, 1982 , vol. 38, # 5 p. 609 - 611
反应条件
zinc(II) chloride in 1,2-dichloro-ethane
T=20°C; 0.5 h;
参考文献
Clarembeau, M.; Krief, A.
Tetrahedron Letters, 1984 , vol. 25, # 33 p. 3625 - 3628
反应条件
1: 1,1-dimethylallyl alcohol With methyl-magnesium chloride in tetrahydrofuran; diethyl ether
T=0°C; 0.5 h;
2: methyl chloroformate in tetrahydrofuran; diethyl ether
T=0 - 20°C; Further stages.;
参考文献
Plietker, Bernd; Dieskau, Andre; Moews, Katrin; Jatsch, Anja
Angewandte Chemie - International Edition, 2008 , vol. 47, # 1 p. 198 - 201
反应条件
(i) Et3N, (ii) H2O, (iii) /BRN= 1633434/; Multistep reaction;
参考文献
Lane,T.H.; Frye,C.L.
Journal of Organometallic Chemistry, 1979 , vol. 172, p. 213 - 221
