2-甲基-3-丁烯-2-醇合成路线 （共 471 条）
反应条件
trifluoromethyl amino ketone in dichloromethane
T=0°C; 0.333333 h; Further byproducts given;
参考文献
Julia, M.; Schmitz, C.
Bulletin de la Societe Chimique de France, 1986 , # 4 p. 630 - 636
反应条件
1: formic acid / 100 °C / Inert atmosphere
2: AlCl3, aluminium chloride / dichloromethane / 1.5 h / -10 - -5 °C / Inert atmosphere
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 3 h / 110 °C / Inert atmosphere
4: potassium carbonate / acetone / 0 - 20 °C / Inert atmosphere
5: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
6: tetrahydrofuran / 0.17 h / 80 °C / Inert atmosphere; Microwave irradiation
7: 6.5 h / 25 °C
View Scheme
参考文献
Harel, Dipak; Khalid, Sami A.; Kaiser, Marcel; Brun, Reto; Wuensch, Bernhard; Schmidt, Thomas J.
Journal of Ethnopharmacology, 2011 , vol. 137, # 1 p. 620 - 625
反应条件
hydrogenchloride; zinc(II) chloride
2.) ether, CH2Cl2, 20 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Mayr, Herbert; Klein, Herbert; Sippel, Elfriede
Chemische Berichte, 1983 , vol. 116, # 11 p. 3624 - 3630
反应条件
hydrogenchloride; zinc(II) chloride
2.) ether, CH2Cl2, -78 deg C, 24 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Mayr, Herbert; Klein, Herbert; Sippel, Elfriede
Chemische Berichte, 1983 , vol. 116, # 11 p. 3624 - 3630
反应条件
hydrogenchloride; zinc oxide; zinc(II) chloride
2.) ether, CH2Cl2, 0 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mayr, Herbert; Klein, Herbert; Sippel, Elfriede
Chemische Berichte, 1983 , vol. 116, # 11 p. 3624 - 3630
反应条件
hydrogenchloride; zinc oxide; zinc(II) chloride
2.) ether, CH2Cl2, 0 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mayr, Herbert; Klein, Herbert; Sippel, Elfriede
Chemische Berichte, 1983 , vol. 116, # 11 p. 3624 - 3630
反应条件
1: 1.) conc. HCl, 2.) ZnCl2, HCl / 2.) ether, CH2Cl2, 20 deg C, 2 h
2: 65 percent / Br2 / CCl4 / 2 h / Ambient temperature
View Scheme
参考文献
Mayr, Herbert; Klein, Herbert; Sippel, Elfriede
Chemische Berichte, 1983 , vol. 116, # 11 p. 3624 - 3630
反应条件
hydrogenchloride; zinc(II) chloride
2.) ether, CH2Cl2, -78 deg C, 24 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Mayr, Herbert; Klein, Herbert; Sippel, Elfriede
Chemische Berichte, 1983 , vol. 116, # 11 p. 3624 - 3630
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
8 h; Heating;
参考文献
Shah; Desai; Trivedi
Pharmazie, 1983 , vol. 38, # 7 p. 439 - 441
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
8 h; Heating;
参考文献
Shah; Desai; Trivedi
Pharmazie, 1983 , vol. 38, # 7 p. 439 - 441
