2-甲基-3-丁烯-2-醇合成路线 （共 471 条）
反应条件
1: 6 g / BF3*Et2O / dioxane / 1 h / Ambient temperature
2: 2.2 g / sodium acetate
3: 420 mg / aqueous ammonia / methanol / cold
4: 275 mg / K2CO3 / acetone
5: 200 mg / aqueous ammonia / methanol / 3 h / 60 °C
6: 120 mg / K2CO3 / acetone
View Scheme
参考文献
Sharma, Padam N.; Shoeb, Aboo; Kapil, Randhir S.; Popli, Satya P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 11 p. 938 - 939
反应条件
1: aqueous H3PO4
2: aqueous NaOH
View Scheme
参考文献
Kachniaschwili et al.
Zhurnal Obshchei Khimii, 1955 , vol. 25, p. 117; engl. Ausg. S. 101
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
1.) room temperature -> 70 deg C, 6 h, 2.) 90 deg C, 4,5 h;
参考文献
Barr, Stephen A.; Neville, Charles F.; Grundon, Michael F.; Boyd, Derek R.; Malone, John F.; Evans, Timothy A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 445 - 452
反应条件
Pd(PPh3)2 in triethylamine
T=70°C; 6 h;
参考文献
Reisch; Iding
Pharmazie, 1993 , vol. 48, # 8 p. 579 - 582
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran
T=50°C; Addition; elimination; 12 h;
参考文献
Shinomiya, Kazuki; Hano, Yoshio; Nomura, Taro
Heterocycles, 2000 , vol. 53, # 4 p. 877 - 886
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane
2: potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 1-phenoxy-2-phenyl-hexahydro-pyrrolo[1,2-c][1,3,2]diazaphopsphole / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Vasil'ev; Lyubimov; Serebryakov; Davankov; Struchkova; Zlotina
Russian Chemical Bulletin, 2010 , vol. 59, # 3 p. 605 - 610
反应条件
1: 0.15 g / BF3.Et2O / dioxane / 1 h / 35 - 40 °C
2: 0.2 g / Zn/cc. HCl / ethanol / 0.5 h / Heating
3: 0.4 g / DDQ / benzene / 0.5 h / Heating
View Scheme
参考文献
Ahluwalia, V. K.; Prakash, Chandra; Gupta, Ranjna
Tetrahedron, 1982 , vol. 38, # 5 p. 609 - 611
反应条件
1: 6 g / BF3*Et2O / dioxane / 1 h / Ambient temperature
2: 1.08 g / sodium acetate
3: 1.4 g / aqueous ammonia / methanol
View Scheme
参考文献
Sharma, Padam N.; Shoeb, Aboo; Kapil, Randhir S.; Popli, Satya P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 11 p. 938 - 939
反应条件
trifluoroacetic acid in nitromethane
T=0°C; 1.5 h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Badet,B.; Julia,M.; Mallet,J.M.
Tetrahedron, 1988 , vol. 44, p. 2913
反应条件
trifluoroacetic acid in nitromethane
T=0°C; 1.5 h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Badet,B.; Julia,M.; Mallet,J.M.
Tetrahedron, 1988 , vol. 44, p. 2913
