2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: acetic acid anhydride; toluene-4-sulfonic acid / beim anschliessenden Erwaermen mit Bimsstein-Pulver 2: iron (III)-chloride; dioxane / 100 °C / 22065.2 - 29420.3 Torr / unter Stickstoff View Scheme
参考文献
Nasarow; Mistrjukow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958 , p. 335,336; engl. Ausg. S. 315, 316
反应条件
propylamine; tetrakis(triphenylphosphine) palladium(0) T=60°C; Substitution; 20 h;
参考文献
Khatyr, Abderrahim; Ziessel, Raymond
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3126 - 3134
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran T=60°C; Sonogashira coupling; 12 h; Inert atmosphere;
参考文献
Yin, Shouchun; Leen, Volker; Jackers, Carine; Beljonne, David; Van Averbeke, Bernard; Van Der Auweraer, Mark; Boens, Noel; Dehaen, Wim
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13247 - 13257
反应条件
sodium amide in ammonia
参考文献
Andrews,S.D. et al.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 2443 - 2449
反应条件
1: 1-bromo-butane With magnesium in tetrahydrofuran; toluene T=40°C; 2: 2-methyl-but-3-yn-2-ol in tetrahydrofuran; toluene 0.5 h; Heating; 3: orthoformic acid triethyl ester in tetrahydrofuran; toluene T=60°C; 4 h;
参考文献
Shchelkunov; Sivolobova; Yashnova
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 5 p. 751 - 752
反应条件
ethylmagnesium bromide 1) CH2Cl2, reflux, 2) RT, 4h; Yield given. Multistep reaction;
参考文献
Poncini, Laurence
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2031 - 2032
反应条件
1: 2-methyl-but-3-yn-2-ol With n-butyllithium in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N-methoxy-N-methyl-(E)-3-phenyl-2-propenamide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane T=-78 - 20°C; 3: With water; ammonium chloride in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane
参考文献
Egi, Masahiro; Azechi, Kenji; Saneto, Moriaki; Shimizu, Kaori; Akai, Shuji
Journal of Organic Chemistry, 2010 , vol. 75, # 6 p. 2123 - 2126
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in acetonitrile 15 h; Ambient temperature;
参考文献
Inoue, Yoshio; Ohuchi, Kunihiro; Imaizumi, Shin
Tetrahedron Letters, 1988 , vol. 29, # 46 p. 5941 - 5942
反应条件
potassium hydroxide; water; hydroquinone reverse Favorskii's reaction;
参考文献
Protsuk; Rybin; Voronkov; Lopyrev
Russian Journal of Applied Chemistry, 1999 , vol. 72, # 9 p. 1658 - 1659
反应条件
ammonium hydroxide; zinc(II) chloride 1.) 20 deg C, 3 h, 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Dzhemilev, U. M.; Selimov, F. A.; Rutman, O. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 11 p. 2343 - 2346
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 11 p. 2600 - 2604
