2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
sodium hydroxide; triethylamine in toluene
参考文献
Montedison S.p.A.
Patent: US4594352 A1, 1986 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper (I) iodide; sodium hydride; triethylamine; triphenylphosphine 1.) reflux, 8 h, 2.) benzene, reflux, 3h; Yield given. Multistep reaction;
参考文献
Inoue, Katsuya; Koga, Noboru; Iwamura, Hiizu
Journal of the American Chemical Society, 1991 , vol. 113, # 26 p. 9803 - 9810
反应条件
1: Sonogashira Cross-Coupling; 5 h; 2: With sodium hydride in toluene T=110°C;
参考文献
Tetrahedron Letters, , vol. 54, # 28 p. 3621 - 3623
反应条件
potassium hydroxide in water T=93°C; 6.41667 h; Heating / reflux;
参考文献
EP1852410 A1, ;
Page/Page column 6 ;
反应条件
sodium hydroxide; 2,2'-azo-bisisobutyronitrile in dichloromethane T=0 - 20°C; 3 h; Product distribution; Further Variations:ReagentsSolventsTemperatures;
参考文献
Calleja-Rubio; Crette; Blancou
Synthesis, 2003 , # 3 p. 361 - 364
反应条件
trifluoroacetic anhydride; copper dichloride Heating;
参考文献
Hiessboeck, Romana; Wolf, Christian; Richter, Elisabeth; Hitzler, Manuela; Chiba, Peter; Kratzel, Martin; Ecker, Gerhard
Journal of Medicinal Chemistry, 1999 , vol. 42, # 11 p. 1921 - 1926
参考文献
Shostakovskii, M. F.; Mirskov, R. G.; Ivanova, N. P.
Doklady Akademii Nauk SSSR, 1969 , vol. 184/189, p. 47 - 49
Doklady Akademii Nauk SSSR, 1969 , vol. 184, p. 366 - 368
反应条件
1: 30 percent / calcium chloride, Cu2Cl2 (95percent brown powder). copper bronze powder, conc. HCl / 1 h / 0 - 5 °C 2: 42 percent / sodamide / liquid ammonia; diethyl ether View Scheme
参考文献
Kopka, Ihor E.; Fataftah, Zacharia A.; Rathke, Michael W.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4616 - 4622
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; Copper(I)chloride in ethyl acetate; acetonitrile
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5463059 A1, 1995 ;
反应条件
1: n-butyl lithium 2: 86 percent / 0.3 mole percent CuCl2 * 2 H2O, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 24 h / 0 °C View Scheme
参考文献
Godfrey, Jollie D.; Mueller, Richard H.; Sedergran, Thomas C.; Soundarajan, Nachimuthu; Colandrea, Vincent J.
Tetrahedron Letters, 1994 , vol. 35, # 35 p. 6405 - 6408
