2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: 59 percent / di-isopropylamine, cuprous bromide / dioxane / 0.5 h / 80 °C 2: cuprous bromide / dioxane / 98 °C View Scheme
参考文献
Searles, Scott; Li, Yushun; Nassim, Bahman; Lopes, Maria-Teresa Robert; Tran, P. T.; Crabbe, Pierre
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 4 p. 747 - 751
反应条件
copper(l) iodide; ammonium iodide; hydrogen iodide; copper in Petroleum ether 3.5 h;
参考文献
Trost, Barry M.; Stiles, Dylan T.
Organic Letters, 2005 , vol. 7, # 11 p. 2117 - 2120
反应条件
{NiBr2(Tri-{n-butyl}-phosphin)2} in hexane 5 h; Heating;
参考文献
Furlani, Anita; Hornemann, Karl Heinz; Russo, Maria Vittoria; Villa, Angiola Chiesi; Guastini, Carlo
Gazzetta Chimica Italiana, 1987 , vol. 117, # 7 p. 429 - 436
反应条件
1: 60 percent / PBr3 / 0.5 h / Ambient temperature 2: 39 percent / Na / ethanol / 4 h / 60 °C 3: 82 percent / NaCl/H2O / dimethylsulfoxide / 19 h / 180 °C 4: 95 percent / LiAlH4 / diethyl ether / 1.) reflux, 1 h; 2.) RT, 10 h 5: 73 percent / oxalyl chloride, DMSO, NEt3 / CH2Cl2 / 1 h / -78 °C View Scheme
参考文献
Rank, Elisabeth; Brueckner, Reinhard
European Journal of Organic Chemistry, 1998 , # 6 p. 1045 - 1053
反应条件
1: n-butyl lithium 2: 86 percent / 0.3 mole percent CuCl2 * 2 H2O, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 24 h / 0 °C View Scheme
参考文献
Godfrey, Jollie D.; Mueller, Richard H.; Sedergran, Thomas C.; Soundarajan, Nachimuthu; Colandrea, Vincent J.
Tetrahedron Letters, 1994 , vol. 35, # 35 p. 6405 - 6408
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=80°C; 48 h;
参考文献
Zou, Haixia; Zhou, Liyan; Li, Yuanzhen; Cui, Yi; Zhong, Hanbing; Pan, Zhengying; Yang, Zhen; Quan, Junmin
Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 994 - 1003
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 0.25 h;
参考文献
Fleming, Fraser F.; Gudipati, Venugopal; Steward, Omar W.
Tetrahedron, 2003 , vol. 59, # 29 p. 5585 - 5593
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -65 deg C, 6 h 2: Hg/Nafion-H, H2O / ethanol / 25 °C View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3078 - 3087
反应条件
triethylamine in dichloromethane
参考文献
Altenbach, Hans-Josef; Korff, Rainer
Tetrahedron Letters, 1981 , vol. 22, # 51 p. 5175 - 5178
反应条件
ammonia; sodium; iron nitrate (III) in diethyl ether T=-33°C;
参考文献
Kondrat'eva,L.A. et al.
Journal of Organic Chemistry USSR (English Translation), 1976 , vol. 12, p. 952 - 956
Zhurnal Organicheskoi Khimii, 1976 , vol. 12, # 5 p. 944 - 948
