2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide 2.) toluene, 100 deg C; Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 38, # 42 p. 7391 - 7394
反应条件
1: 86 percent / PdCl2, PPh3, CuI / triethylamine; dimethylformamide 2: 52 percent / BBr3 / CH2Cl2 / 0.17 h / -70 °C 3: 63 percent / PhCOOH / Ambient temperature; macroelectrolysis: mercury pool working electrode, tetraethylammonium p-toluenesulfonate supporting electrolyte View Scheme
参考文献
Heterocycles, , vol. 45, # 6 p. 1131 - 1142
反应条件
1: 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in toluene T=80°C; Sonogashira coupling; 1 h; 2: para-iodoanisole With sodium hydride T=110°C; Sonogashira coupling;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
反应条件
potassium phosphate; triphenylphosphine; palladium diacetate in dimethyl sulfoxide T=80°C; 48 h;
参考文献
Shirakawa, Eiji; Kitabata, Takaaki; Otsuka, Hidehito; Tsuchimoto, Teruhisa
Tetrahedron, 2005 , vol. 61, # 41 p. 9878 - 9885
反应条件
pyrrolidine; Najera palladacycle I; 4-laurylbenzenesulfonic acid sodium salt; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiationSealed tubeGreen chemistry; chemoselective reaction;
参考文献
European Journal of Organic Chemistry, , # 26 p. 5864 - 5870
反应条件
pyrrolidine; Najera palladacycle I; 4-laurylbenzenesulfonic acid sodium salt; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiationSealed tubeGreen chemistry;
参考文献
European Journal of Organic Chemistry, , # 26 p. 5864 - 5870
反应条件
copper(l) iodide; triethylamine; triphenylphosphine T=90°C; Sonogashira coupling; 3 h; Inert atmosphere;
参考文献
Molecules, , vol. 15, # 12 p. 9157 - 9173
反应条件
copper(l) iodide; diisopropylamine; triphenylphosphine; palladium on activated charcoal in N,N-dimethyl acetamide; water T=80°C; Sonogashira coupling; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 8 p. 3327 - 3329
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine Inert atmosphereSealed flaskHeating;
参考文献
Tetrahedron, , vol. 68, # 13 p. 2844 - 2850
反应条件
sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-benzyl-N,N,N-triethylammonium chloride in benzene Ambient temperature; Yield given;
参考文献
Synthesis, , # 7 p. 571 - 572
