2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
sodium hydroxide; 2,2'-azo-bisisobutyronitrile in dichloromethane
T=0 - 20°C; 3 h; Product distribution; Further Variations:SolventsTemperaturesreaction time;
参考文献
Calleja-Rubio; Crette; Blancou
Synthesis, 2003 , # 3 p. 361 - 364
反应条件
1: methanol; HgO; BF3-etherate / 45 - 55 °C / Reagens 4: Trichloressigsaeure
2: diluted HCl
3: aq. NaOH solution / 60 °C
View Scheme
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940 , p. 219
Chem.Abstr., 1942 , p. 746
反应条件
1: 2-methyl-but-3-yn-2-ol With triethylamine in dichloromethane
T=-85°C; 0.166667 h;
2: benzenesulfenyl chloride in dichloromethane
T=-85 - 20°C;
参考文献
Ma, Shengming; Ren, Hongjun; Wei, Qi
Journal of the American Chemical Society, 2003 , vol. 125, # 16 p. 4817 - 4830
反应条件
copper acetylacetonate; iron (III) acetylacetonate; potassium carbonate in N,N-dimethyl-formamide
T=50°C; 24 h;
参考文献
Meng, Xu; Li, Chuanbin; Han, Baochun; Wang, Tiansheng; Chen, Baohua
Tetrahedron, 2010 , vol. 66, # 23 p. 4029 - 4031
反应条件
formic acid; hydroquinone
参考文献
Ansell et al.
Journal of the Chemical Society, 1956 , p. 911,914
反应条件
1: 70 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 8 h / 80 °C
2: H2 / Raney Ni / methanol / 20 °C
3: 85 percent / TsOH*H2O / toluene / Heating
View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: 72 percent / Ac2O, conc. H2SO4 / 50 °C
2: 85 percent / CuI, Et2NH / <Pd(PPh3)2Cl2> / Ambient temperature
3: 78 percent / 12N HCl, HOAc / 8 h / Ambient temperature
View Scheme
参考文献
Defranq, Eric; Zesiger, Thierry; Tabacchi, Raffaele
Helvetica Chimica Acta, 1993 , vol. 76, # 1 p. 425 - 430
反应条件
ion-exchange resin lt;H+ formgt; in acetic acid
3.5 h; Heating;
参考文献
Apparu,M.; Glenat,R.
Bulletin de la Societe Chimique de France, 1968 , p. 1106 - 1112
反应条件
1: iodobenzene; 2-methyl-but-3-yn-2-ol With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine
T=50°C; 1 h; Inert atmosphere;
2: 4-hydroxyiodobenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hydroxide
T=110°C; 5 h; Heating;
参考文献
Zhao, Yankai; Liu, Qiang; Li, Jing; Liu, Zhongquan; Zhou, Bo
Synlett, 2010 , # 12 p. 1870 - 1872
反应条件
1: iodobenzene; 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride
T=80°C; Sonogashira coupling;
2: O-triisopropylsilyl-2-iodophenol With potassium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride
T=80°C; Sonogashira coupling;
3: With tetrabutyl ammonium fluoride in tetrahydrofuran
T=80°C; Further stages.;
参考文献
Csekei, Marton; Novak, Zoltan; Kotschy, Andras
Tetrahedron, 2008 , vol. 64, # 37 p. 8992 - 8996
