2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: NaNH2
2: Br2, NaOH
View Scheme
参考文献
Ziegler,G.R. et al.
Journal of the American Chemical Society, 1963 , vol. 85, p. 1648 - 1651
反应条件
1: 56 percent / nBuLi
2: 59 percent / LiAlH4
View Scheme
参考文献
Cutting, Ian; Parsons, Philip J.
Journal of the Chemical Society, Chemical Communications, 1983 , # 21 p. 1209 - 1210
反应条件
T=40°C; 4 h; further temperature: 20 deg C, various reaction times; Product distribution;
参考文献
Julia, Marc; Lefebvre, Christian
Tetrahedron Letters, 1984 , vol. 25, # 2 p. 189 - 192
参考文献
Jordan, Robert W.; Villeneuve, Karine; Tam, William
Journal of Organic Chemistry, 2006 , vol. 71, # 15 p. 5830 - 5833
参考文献
Petrow,V. et al.
Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 37 - 48
反应条件
1: 92 percent / KOH / neat (no solvent) / 0.25 h / 75 - 120 °C
2: 1.) KH, n-butyllithium / 1.) THF, 0 deg C, 60 min, hexane, -78 deg C, 1 h; 2.) from -78 deg C to room t., overnight
3: 51 percent / methyl iodide / acetonitrile; H2O / 3 h / 60 °C
View Scheme
参考文献
Ruel, Odile; Ekogha, Cyriaque Bibang Bi; Lorne, Robert; Julia, Sylvestre A.
Bulletin de la Societe Chimique de France, 1985 , # 6 p. 1250 - 1260
反应条件
copper(l) iodide; N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in water; toluene
T=70°C; 120 h;
参考文献
Albrecht, Marcel; Nieger, Martin; Schmidt, Andreas
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012 , vol. 67, # 2 p. 103 - 106
反应条件
1: para-iodoanisole; 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in toluene
T=80°C; Sonogashira coupling; 1 h;
2: iodobenzene With sodium hydride
T=110°C; Sonogashira coupling;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
反应条件
1: 75 percent / Et3N, PdCl2, PPh3, CuI / dimethylformamide / 2 h / 80 °C
2: 74 percent / H2 / Pd/C / methanol; ethyl acetate / 15 - 18 °C
3: 70 percent / K2CO3 / acetone / 7 h / Heating
4: 112 mg / TsOH*H2O / toluene / 1 h / 115 °C
5: 88 percent / aq. NaOH / methanol; dioxane / 0.67 h / 45 °C
View Scheme
参考文献
Tsukayama, Masao; Li, He; Tsurumoto, Ken; Nishiuchi, Masaki; Kawamura, Yasuhiko
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 11 p. 2673 - 2680
反应条件
1: Et3N, DMAP / CH2Cl2 / 2 h / Ambient temperature
2: CuCl, Et3N / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
