2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: copper(l) chloride; hydroxylamine hydrochloride; N-butylamine / water / 0.17 h / 0 °C / |Inert atmosphere
2: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 0.17 h / 0 °C / |Inert atmosphere
View Scheme
参考文献
Wang, Kung-Pern; Cho, Eun Jin; Yun, Sang Young; Rhee, Jee Young; Lee, Daesung
Tetrahedron, 2013 , vol. 69, # 43 p. 9105 - 9110
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine
T=65°C; 6 h;
参考文献
Li, Jie; Huang, Pengcheng
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 426 - 431
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
Sonogashira Cross-Coupling; Inert atmosphereReflux;
参考文献
Smeyanov, Alexey; Schmidt, Andreas
Synthetic Communications, 2013 , vol. 43, # 20 p. 2809 - 2816
反应条件
1.1: 55 percent / sodium hypochlorite; triethylamine / H2O; CHCl3 / 0 - 4 °C
2.1: hydrogen / Pd/C / methanol / 10 h
2.2: 72 percent / aqueous hydrochloric acid / H2O / 3 h
3.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -78 °C
3.2: 70 percent / tetrahydrofuran; heptane; ethylbenzene / 3 h / -78 °C
4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Dall'Acqua, Francesco; Viola, Giampietro
Tetrahedron, 2003 , vol. 59, # 28 p. 5215 - 5223
反应条件
toluene-4-sulfonic acid; triphenylphosphine; palladium diacetate in tetrahydrofuran
T=100°C; P=20685.9 Torr; 48 h; Yields of byproduct given;
参考文献
Xiao, Wen-Jing; Alper, Howard
Journal of Organic Chemistry, 1997 , vol. 62, # 11 p. 3422 - 3423
反应条件
tetrakis(triphenylphosphine) palladium(0) in benzene
T=100°C; Cyclization; condensation; P=45600 Torr; 50 h;
参考文献
Ogawa, Akiya; Kuniyasu, Hitoshi; Sonoda, Noboru; Hirao, Toshikazu
Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8361 - 8365
参考文献
Guermont
Bulletin de la Societe Chimique de France, 1953 , p. 386,389
Mem. Services chim., 1955 , vol. 40, p. 147,169
参考文献
Pudowik
Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1462,1467; engl. Ausg. S. 1593, 1598
反应条件
1: 79 percent / Triethylamin / CH2Cl2
2: 1.) Et2NH or EtOH, 2.) 10percent aq. HCl / 1.) ether, room temp., 12 h, 2.) 24h, room temp.
View Scheme
参考文献
Altenbach, Hans-Josef; Korff, Rainer
Tetrahedron Letters, 1981 , vol. 22, # 51 p. 5175 - 5178
反应条件
potassium hydroxide; diethyl ether
参考文献
Colonge; Clerc
Bulletin de la Societe Chimique de France, 1954 , p. 1454,1457
