2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: und anschliessenden Behandeln mit Chlor-trimethyl-silan
2: palladium; ethanol / Hydrogenation
View Scheme
参考文献
Schostakowskii et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1956 , p. 1271,1273
Chem.Abstr., 1957 , p. 5689
反应条件
1.1: 94 percent / CaCl2; CuCl2; copper bronze / aq. HCl / 1 h / 0 °C
2.1: EtONa / ethanol / 0.5 h / 60 °C
2.2: 62 percent / ethanol / 16.5 h / Heating
3.1: 88 percent / aq. NaBr / dimethylsulfoxide / 20 h / 190 °C
4.1: 90 percent / LiAlH4 / diethyl ether / 15 h
View Scheme
参考文献
Rank, Elisabeth; Brueckner, Reinhard
European Journal of Organic Chemistry, 1998 , # 6 p. 1045 - 1053
反应条件
1: 1) EtMgBr, 2) conc. HCl
2: 75 percent / Mg / tetrahydrofuran / Ambient temperature
3: 85 percent / AgNO3, KCN / Ambient temperature
4: 100 percent / H2, quinoline / Pd-BaSO4
View Scheme
参考文献
Cai, Jiaqiang; Davies, Alwyn G.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 10 p. 1743 - 1746
反应条件
copper(l) iodide; triethylamine; triphenylphosphine
T=90°C; Sonogashira coupling; 3 h; Inert atmosphere;
参考文献
Lin, Bo-Nan; Huang, Shao-Hsien; Wu, Wei-Yi; Mou, Chung-Yuan; Tsai, Fu-Yu
Molecules, 2010 , vol. 15, # 12 p. 9157 - 9173
反应条件
1,1-diphenyl-2-(dicyclohexylphosphino)propene; copper(l) iodide; diisopropylamine; palladium in N,N-dimethyl-formamide
T=100°C; 23 h;
参考文献
Takasago International Corporation
Patent: EP1167372 A1, 2002 ;
Location in patent: Example 38 ;
反应条件
triphenylphosphine; copper monoiodide in triethylamine
参考文献
Seiko Epson Corporation
Patent: US5437815 A1, 1995 ;
反应条件
copper(l) iodide; triethylamine; triphenylphosphine
T=90°C; Sonogashira coupling; 3 h; Inert atmosphere;
参考文献
Lin, Bo-Nan; Huang, Shao-Hsien; Wu, Wei-Yi; Mou, Chung-Yuan; Tsai, Fu-Yu
Molecules, 2010 , vol. 15, # 12 p. 9157 - 9173
反应条件
diisopropylamine in N,N-dimethyl-formamide
参考文献
Suzuki, Ken; Kobayashi, Tohru; Nishikawa, Takenobu; Hori, Yoji; Hagiwara, Toshimitsu
Patent: US2002/58837 A1, 2002 ;
反应条件
1: CuI, Et3N / Pd(PPh3)2Cl2 / 15 h
2: 54 percent / diethylamine / ethanol / 24 h / Heating
View Scheme
参考文献
Bhat, Abhijit S.; Whetstone, Jennifer L.; Brueggemeier, Robert W.
Tetrahedron Letters, 1999 , vol. 40, # 13 p. 2469 - 2472
反应条件
1: 50 percent / TsOH / benzene / Heating
2: 1.), 2.) PCC
View Scheme
参考文献
Bernard-Henriet, Christiane D.; Grimaldi, Jacques R.; Hatem, Jacques M.
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3699 - 3702
