2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
copper(l) iodide; dibutylamine; perfluoro-tagged Pd in N,N-dimethyl-formamide
T=100°C; 4 h;
参考文献
Lin, Bo-Nan; Huang, Shao-Hsien; Wu, Wei-Yi; Mou, Chung-Yuan; Tsai, Fu-Yu
Molecules, 2010 , vol. 15, # 12 p. 9157 - 9173
反应条件
copper(l) iodide; 1-isobutyl-2,2,6,6-tetramethyl-phosphorinane*HBF4; diisopropylamine; bis(benzonitrile)palladium(II) dichloride in 1,4-dioxane
T=20°C; Sonogashira reaction; 6 h;
参考文献
Brenstrum, Tim; Clattenburg, Julie; Britten, James; Zavorine, Serguei; Dyck, Jeff; Robertson, Alan J.; McNulty, James; Capretta, Alfredo
Organic Letters, 2006 , vol. 8, # 1 p. 103 - 105
反应条件
polymethylhydrosiloxane; cesium fluoride; copper(l) chloride; bis-triphenylphosphine-palladium(II) chloride in 1-methyl-pyrrolidin-2-one
T=20°C; Sonogashira reaction; 4 h;
参考文献
Gallagher, William P.; Maleczka Jr., Robert E.
Synlett, 2003 , # 4 p. 537 - 541
反应条件
polymethylhydrosiloxane; cesium fluoride; copper(l) chloride; bis-triphenylphosphine-palladium(II) chloride in 1-methyl-pyrrolidin-2-one
T=20°C; Sonogashira reaction; 5 h;
参考文献
Gallagher, William P.; Maleczka Jr., Robert E.
Synlett, 2003 , # 4 p. 537 - 541
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=25°C; Sonogashira coupling; 6 h;
参考文献
Gallagher, William P.; Maleczka Jr., Robert E.
Journal of Organic Chemistry, 2003 , vol. 68, # 17 p. 6775 - 6779
反应条件
2,6-dimethylpyridine in dichloromethane
T=20°C; 18 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/49889 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1H-imidazole in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Vahabi, Roza; Frey, Wolfgang; Pietruszka, Joerg
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11549 - 11559
反应条件
2-(N,N-dimethylamino)-pyridine in water; N,N-dimethyl-formamide
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: EP796843 A2, 1997 ;
反应条件
1: 84 percent / NH3, Fe(NO3)3, Li / diethyl ether / 1 h / -40 °C
2: 71 percent / HCl, CaCl2 / petroleum ether
View Scheme
参考文献
Mayr, Herbert; Halberstadt-Kausch, Inge K.
Chemische Berichte, 1982 , vol. 115, # 11 p. 3479 - 3515
反应条件
tributylphosphine
T=100°C; P=75006 Torr; 15 h;
参考文献
Kayaki, Yoshihito; Yamamoto, Masafumi; Ikariya, Takao
Journal of Organic Chemistry, 2007 , vol. 72, # 2 p. 647 - 649
