2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
lithium amide in diethyl ether
T=-40°C;
参考文献
Mayr, Herbert; Halberstadt-Kausch, Inge K.
Chemische Berichte, 1982 , vol. 115, # 11 p. 3479 - 3515
参考文献
Shchelkunov,A.V. et al.
Doklady Chemistry, 1979 , vol. 245, p. 125 - 126
Dokl. Akad. Nauk SSSR Ser. Khim., 1979 , vol. 245, # 2 p. 380 - 382
反应条件
1: ethyl acetoacetate <Ni salt>, Py
2: KOH / 115 - 130 °C / 12 Torr
View Scheme
参考文献
Akopyan,L.A. et al.
Journal of Organic Chemistry USSR (English Translation), 1973 , vol. 9, p. 2020 - 2022
Zhurnal Organicheskoi Khimii, 1973 , vol. 9, # 10 p. 2004 - 2006
反应条件
1: 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride
T=50°C; Sonogashira coupling; 1 h;
2: 1-bromo-2-chloro-benzene With potassium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride
T=110°C; Sonogashira coupling; 5 h;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
反应条件
SPhos; C16H16Cl2N2O4Pd2; N-hexadecyl-N,N,N-trimethylammonium bromide; triethylamine in water
T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208
反应条件
1.1: 25 percent / HCl / 3 h / 0 - 25 °C
2.1: K2CO3; KI; CuI / acetone / 1 h / Heating
2.2: 90 percent / acetone; dimethylformamide / 15 h / 150 °C
View Scheme
参考文献
Tisdale, Eric J.; Vong, Binh G.; Li, Hongmei; Kim, Sun Hee; Chowdhury, Chinmay; Theodorakis, Emmanuel A.
Tetrahedron, 2003 , vol. 59, # 35 p. 6873 - 6887
反应条件
diethylamino-sulfur trifluoride in diethylene glycol dimethyl ether
T=-78 - -50°C;
参考文献
Guirgis, Gamil A.; Bell, Stephen; Groner, Peter; Zheng, Chao; Durig, James R.
Physical Chemistry Chemical Physics, 2004 , vol. 6, # 15 p. 3919 - 3927
反应条件
1: methanol; HgO; BF3-etherate / 45 - 55 °C / Reagens 4: Trichloressigsaeure
2: diluted HCl
3: sodium; ethanol
View Scheme
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940 , p. 219
Chem.Abstr., 1942 , p. 746
反应条件
sodium hydroxide; 2,2'-azo-bisisobutyronitrile in dichloromethane
T=0 - 20°C; 3 h; Product distribution; Further Variations:ReagentsSolventsTemperatures;
参考文献
Calleja-Rubio; Crette; Blancou
Synthesis, 2003 , # 3 p. 361 - 364
反应条件
ammonia; sodium; iron nitrate (III) in diethyl ether
T=-33°C;
参考文献
Kondrat'eva,L.A. et al.
Journal of Organic Chemistry USSR (English Translation), 1976 , vol. 12, p. 952 - 956
Zhurnal Organicheskoi Khimii, 1976 , vol. 12, # 5 p. 944 - 948
