2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
T=40°C; 4 h; further temperature: 20 deg C, various reaction times; Product distribution;
参考文献
Julia, Marc; Lefebvre, Christian
Tetrahedron Letters, 1984 , vol. 25, # 2 p. 189 - 192
反应条件
[Pd(NCCH3)2(PPh3)2](BF4)2 in tetrahydrofuran
T=50°C; P=7355.08 Torr; Yield given. Yields of byproduct given;
参考文献
Matsushita, Koichi; Komori, Tsunenori; Oi, Shuichi; Inoue, Yoshio
Tetrahedron Letters, 1994 , vol. 35, # 32 p. 5889 - 5890
反应条件
1: tetracarbonyl nickel; hydrogen chloride
2: aqueous methanol. KOH-solution
View Scheme
参考文献
Jones et al.
Journal of the Chemical Society, 1957 , p. 4628,4631
反应条件
1: 78 percent / propionic acid / 12 h / 130 °C
2: 95 percent / LiAlH4 / diethyl ether / 0.5 h
3: 78 percent / pyridine / 2 h / 0 °C
4: 95 percent / dimethylsulfoxide / 48 h / 20 °C
5: 81 percent / NaOH / ethanol; H2O / Heating
6: 91 percent / LiAlH4 / diethyl ether / 0.5 h
View Scheme
参考文献
Jonasson; Horvath; Backvall
Journal of the American Chemical Society, 2000 , vol. 122, # 40 p. 9600 - 9609
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=20°C; Sonogashira reaction; 15 h;
参考文献
Rodriguez, J. Gonzalo; Tejedor, J. Luis
Tetrahedron, 2005 , vol. 61, # 8 p. 2047 - 2054
反应条件
pyridine; p-toluenesulfonyl chloride
参考文献
Hennion; Barrett
Journal of the American Chemical Society, 1957 , vol. 79, p. 2146
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=0°C; 0.5 h;
参考文献
Nicolaou; Sasmal, Pradip K.; Xu, Hao
Journal of the American Chemical Society, 2004 , vol. 126, # 17 p. 5493 - 5501
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride in acetonitrile
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5463059 A1, 1995 ;
反应条件
phosphorus tribromide
Inert atmosphere;
参考文献
Trost, Barry M.; Frontier, Alison J.; Thiel, Oliver R.; Yang, Hanbiao; Dong, Guangbin
Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9762 - 9776
反应条件
(i) PBr3, Py, (ii) (heating); Multistep reaction;
参考文献
Jacobs,T.L.; Petty,W.L.
Journal of Organic Chemistry, 1963 , vol. 28, p. 1360 - 1366
