2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
hydrogen bromide; copper(I) bromide
参考文献
Mayr, Herbert; Halberstadt-Kausch, Inge K.
Chemische Berichte, 1982 , vol. 115, # 11 p. 3479 - 3515
反应条件
1: 2-Chloro-5-pyridinecarboxylicacid ethylester With potassium carbonate; copper(l) iodide; palladium 10 on activated carbon; triphenylphosphine in ethylene glycol dimethyl ether; water
2: 2-methyl-but-3-yn-2-ol in ethylene glycol dimethyl ether; water
T=80°C; 2.5 h;
参考文献
Frigoli, Samuele; Fuganti, Claudio; Malpezzi, Luciana; Serra, Stefano
Organic Process Research and Development, 2005 , vol. 9, # 5 p. 646 - 650
反应条件
(i) aq. HCl, CuCl, (ii) /BRN= 635746/; Multistep reaction;
参考文献
Fowler
The Journal of organic chemistry, 1977 , vol. 42, # 15 p. 2637 - 2637
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; zinc(II) chloride
1.) THF, hexane, -78 deg C, 1.5 h; -78 deg C to 0 deg C; 0 deg C, 3 h, 2.) 65 deg C, 33 h; Yield givenMultistep reaction;
参考文献
Mori, Hajime; Ikoma, Keiichi; Isoe, Sachihiko; Kitaura, Kazuo; Katsumura, Shigeo
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8704 - 8718
反应条件
MoO2Cl2*(dmf)2 in dichloromethane
T=20°C; 0.333333 h;
参考文献
Stock, Christian; Brueckner, Reinhard
Synlett, 2010 , # 16 p. 2429 - 2434
反应条件
1: Py / CH2Cl2
View Scheme
参考文献
Carpino,L.A. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 3291 - 3295
参考文献
Nasarow; Schwechgeimer
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 457,460; engl. Ausg. S. 459, 461
反应条件
ammonium hydroxide; zinc(II) chloride
1.) 20 deg C, 3 h, 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Dzhemilev, U. M.; Selimov, F. A.; Rutman, O. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 11 p. 2343 - 2346
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 11 p. 2600 - 2604
反应条件
ethylmagnesium bromide in diethyl ether
参考文献
Shchelkunov,A.V. et al.
Doklady Chemistry, 1979 , vol. 245, p. 125 - 126
Dokl. Akad. Nauk SSSR Ser. Khim., 1979 , vol. 245, # 2 p. 380 - 382
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tris(4-methylphenyl)-phosphine in tetrahydrofuran
T=80°C; Sonogashira Cross-Coupling; 6 h; Inert atmosphereSchlenk technique;
参考文献
Caporale, Andrea; Tartaggia, Stefano; Castellin, Andrea; De Lucchi, Ottorino
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 384 - 393
