2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
(i) EtMgBr, (ii) /BRN= 2636379/; Multistep reaction;
参考文献
Kuznetsova,V.P. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, # 6 p. 1864 - 1867,1875 - 1878
参考文献
Spaeth; Hillel
Chemische Berichte, 1939 , vol. 72, p. 963,2093
反应条件
triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in triethylamine
T=70°C; 15 h;
参考文献
Ting, Ching-Hua; Chen, Jiun-Tai; Hsu, Chain-Shu
Macromolecules, 2002 , vol. 35, # 4 p. 1180 - 1189
反应条件
1: triethylamine; copper(l) iodide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 80 °C / |Inert atmosphere
2: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 4 h / 20 °C
View Scheme
参考文献
Gschneidtner, Tina A.; Moth-Poulsen, Kasper
Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5426 - 5429
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Marco-Contelles, Jose; Balme, Genevieve; Bouyssi, Didier; Destabel, Christine; Henriet-Bernard, Christiane D.; Grimaldi; Hatem, Jacques M.
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1202 - 1209
参考文献
Nilsen, Nils Olav; Skatteboel, Lars; Stenstroem, Yngve
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, p. 459 - 461
反应条件
copper(l) iodide in water
T=30°C; 72 h;
参考文献
Bieber, Lothar W.; Da Silva, Margarete F.
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8281 - 8283
反应条件
copper(l) iodide
Heating;
参考文献
Gevorkyan; Movsisyan; Dzhandzhulyan; Arakelyan; Petrosyan
Russian Journal of General Chemistry, 2008 , vol. 78, # 3 p. 504 - 505
反应条件
copper(l) iodide
Heating;
参考文献
Gevorkyan; Movsisyan; Dzhandzhulyan; Arakelyan; Petrosyan
Russian Journal of General Chemistry, 2008 , vol. 78, # 3 p. 504 - 505
反应条件
18-crown-6 ether; N,N'-(2,9-di-c-hexyl-10-phenanthryl)2-4,5-diHimidazolium hexafluorophosphate; potassium tert-butylate; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=65°C; Sonogashira coupling reaction; 3 h;
参考文献
Hundertmark, Thomas; Littke, Adam F.; Buchwald, Stephen L.; Fu, Gregory C.
Organic Letters, 2000 , vol. 2, # 12 p. 1729 - 1731
