2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
copper(l) iodide; tetra-(n-butyl)ammonium iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=70°C; 2.5 h;
参考文献
Mori, Hajime; Matsuo, Takafumi; Yoshioka, Yasunori; Katsumura, Shigeo
Journal of Organic Chemistry, 2006 , vol. 71, # 24 p. 9004 - 9012
反应条件
SPhos; C16H16Cl2N2O4Pd2; N-hexadecyl-N,N,N-trimethylammonium bromide; triethylamine in water
T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208
反应条件
1: 90.5 percent / chlorine; NaOH / H2O; benzene / 1 h / 20 °C
2: magnesium / methoxybenzene; tetrahydrofuran / 4 h / 40 - 45 °C
View Scheme
参考文献
Shchelkunov; Sivolobova; Mataeva; Minbaev; Muldakhmetov
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 1 p. 5 - 8
反应条件
sulfuric acid
0.5 h;
参考文献
Phillips, Catherine; Jacobson, Roy; Abrahams, Barbara; Williams, Howard J.; Smith, Leverett R.
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1920 - 1924
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tris(4-methylphenyl)-phosphine in tetrahydrofuran
T=80°C; Sonogashira Cross-Coupling; 6 h; Inert atmosphereSchlenk technique;
参考文献
Caporale, Andrea; Tartaggia, Stefano; Castellin, Andrea; De Lucchi, Ottorino
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 384 - 393
反应条件
piperidine; bis-triphenylphosphine-palladium(II) chloride in various solvent(s)
Sonogashira coupling; 2 h; Heating;
参考文献
Fukuyama, Takahide; Shinmen, Masutaka; Nishitani, Satoshi; Sato, Masaaki; Ryu, Ilhyong
Organic Letters, 2002 , vol. 4, # 10 p. 1691 - 1694
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=100°C; 6 h;
参考文献
Oi, Shuichi; Orihara, Hideki; Kawai, Hiroshi; Inoue, Yoshio
Heterocycles, 2005 , vol. 66, # 1 p. 621 - 625
反应条件
SPhos; C16H16Cl2N2O4Pd2; N-hexadecyl-N,N,N-trimethylammonium bromide; triethylamine in water
T=130°C; Sonogashira Cross-Coupling; 0.5 h; Microwave irradiation;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 203 - 208
反应条件
polyvanadioorganosiloxane (3.1percent V) in xylene
T=150 - 160°C; 6 h; Further byproducts given;
参考文献
Erman, M. B.; Aul'chenko, I. S.; Kheifits, L. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , p. 21 - 28
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 1 p. 23 - 31
反应条件
polyvanadioorganosiloxane (3.1percent V) in xylene
T=150 - 160°C; 6 h; MechanismRate constantProduct distribution;
参考文献
Erman, M. B.; Aul'chenko, I. S.; Kheifits, L. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , p. 21 - 28
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 1 p. 23 - 31
