2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
ethylmagnesium bromide in diethyl ether
参考文献
Shchelkunov; Sivolobova; Mataeva; Minbaev; Muldakhmetov
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 1 p. 5 - 8
反应条件
1: 70 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 8 h / 80 °C
2: H2 / Raney Ni / methanol / 20 °C
View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: iodobenzene; 2-methyl-but-3-yn-2-ol With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine
T=50°C; 1 h; Inert atmosphere;
2: 1-chloro-4-iodobenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hydroxide
T=110°C; 5 h; Inert atmosphere;
参考文献
Zhao, Yankai; Liu, Qiang; Li, Jing; Liu, Zhongquan; Zhou, Bo
Synlett, 2010 , # 12 p. 1870 - 1872
反应条件
hydrogen; pentacyanocobaltate(II)(3-) in water
T=45°C; P=760 Torr; 10 h; <Me2C(OH)CCH>/<Co> : 1; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Funabiki, Takuzo; Yamazaki, Yasuyuki; Sato, Yoshihiro; Yoshida, Satohiro
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , # 12 p. 1915 - 1918
反应条件
hydrogen in water
T=45°C; P=760 Torr; 10 h; <Me2C(OH)CCH>/<Co> : 2; Yield given. Yields of byproduct given;
参考文献
Funabiki, Takuzo; Yamazaki, Yasuyuki; Sato, Yoshihiro; Yoshida, Satohiro
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , # 12 p. 1915 - 1918
反应条件
pentacyanocobaltate(II)(3-); hydrogen in water
P=760 Torr; 10 h; different reagent ratio; Product distributionMechanism;
参考文献
Funabiki, Takuzo; Yamazaki, Yasuyuki; Sato, Yoshihiro; Yoshida, Satohiro
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , # 12 p. 1915 - 1918
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=60°C; Sonogashira cross-coupling/cyclization; 24 h;
参考文献
Bernini, Roberta; Cacchi, Sandro; De Salve, Ilse; Fabrizi, Giancarlo
Synthesis, 2007 , # 6 p. 873 - 882
参考文献
Spaeth; Hillel
Chemische Berichte, 1939 , vol. 72, p. 963,2093
参考文献
Spaeth; Hillel
Chemische Berichte, 1939 , vol. 72, p. 963,2093
反应条件
trichlorophosphate in chloroform
210 h; Heating;
参考文献
Reisch, Johannes; Bathe, Andreas; Salehi-Artimani, Reza A.
Archiv der Pharmazie (Weinheim, Germany), 1986 , vol. 319, # 8 p. 720 - 727
