2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
(i) MeSOCl, Et3N, CH2Cl2, (ii) /BRN= 3535403/, CuBr, THF; Multistep reaction;
参考文献
Vermeer,P. et al.
Recueil des Travaux Chimiques des Pays-Bas, 1978 , vol. 97, p. 56 - 58
反应条件
(i) PCl3, Et3N, (ii) aq. Ba(OH)2, (iii) aq. HCl; Multistep reaction;
参考文献
Macomber,R.S.; Kennedy,E.R.
Journal of Organic Chemistry, 1976 , vol. 41, p. 3191 - 3197
反应条件
pyridine; ethyl acetoacetate lt;Ni saltgt;
参考文献
Richard, Marcia E.; Reese, Kyle P.; Stone, Joshua J.; Pickett, Phillip D.; Tillman, Eric S.; Stockland Jr., Robert A.
Journal of Organometallic Chemistry, 2011 , vol. 696, # 1 p. 123 - 129
反应条件
Ni(PPh3)4 in tetrahydrofuran 17 h; Ambient temperature;
参考文献
Bhatarah, Parveen; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 9 p. 2603 - 2606
反应条件
tris (triphenylphosphine)rhodium(I) chloride T=25°C; 18 h; Inert atmosphere;
参考文献
Richard, Marcia E.; Reese, Kyle P.; Stone, Joshua J.; Pickett, Phillip D.; Tillman, Eric S.; Stockland Jr., Robert A.
Journal of Organometallic Chemistry, 2011 , vol. 696, # 1 p. 123 - 129
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0°C; 1 h;
参考文献
Salomon; Basu; Roy; Sachinvala
Journal of the American Chemical Society, 1991 , vol. 113, # 8 p. 3096 - 3106
反应条件
1: 1.) n-butyllithium; 2.) mercurous chloride, cuprous chloride / 1.) hexane, THF, -78 deg C, 1 h; 2.) hexane, THF, -78 deg C --> room temp., then reflux, 5.5 h 2: 1.) EtMgBr / 2.) CuCl / 1.) THF, 50 deg C, 30 min; 2.) THF, 50-55 deg C, 2 h 3: 82 percent / acetyl chloride, stannic chloride / CH2Cl2 / 0.25 h / 10 - 15 °C View Scheme
参考文献
Shostakovskii,M.F. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1962 , p. 472 - 474
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1962 , # 3 p. 512 - 515
反应条件
copper(l) iodide; potassium carbonate; triphenylphosphine; palladium on activated charcoal in ethylene glycol dimethyl ether; water
参考文献
Cosford; Bleicher; Herbaut; McCallum; Vernier J.-; Dawson; Whitten; Adams; Chavez-Noriega; Correa; Crona; Mahaffy; Menzaghi; Rao; Reid; Sacaan; Santori; Stauderman; Whelan; et
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3235 - 3237
反应条件
in dichloromethane T=25°C; 3 h;
参考文献
Macomber, Roger S.; Krudy, George A.; Seff, Karl; Rendon-Diazmiron, L. E.
Journal of Organic Chemistry, 1983 , vol. 48, # 9 p. 1425 - 1430
反应条件
1: Py 2: aq. HCl View Scheme
参考文献
Cherbuliez,E. et al.
Helvetica Chimica Acta, 1965 , vol. 48, p. 632 - 642
