3-羟基-3-甲基-2-丁酮合成路线 （共 82 条）
反应条件
potassium hydroxide
T=50 - 90°C;
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940 , p. 219
Chem.Abstr., 1942 , p. 746
反应条件
1: 50 percent / n-BuLi; diisopropylamine / tetrahydrofuran; hexane
2: 60 percent / CeCl3*7H2O; NaI / acetonitrile
3: 41 percent / O2; CuCl; Na2HPO4 / PdCl2 / 1,2-dimethoxy-ethane / 50 °C
View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Jerris, Paula J.; Scarborough, Robert M.; Wovkulich, Peter M.
Journal of the American Chemical Society, 1981 , vol. 103, # 6 p. 1501 - 1513
反应条件
1: 2-methyl-2-hydroxy-butan-3-one; diethyl malonate With sodium ethanolate in ethanol
T=20°C; 0.5 h;
2: 5-azapyrimidine in ethanol
T=20°C; 3 h;
3: methyl iodide in ethanol
T=20°C; 20 h;
参考文献
Villemin, Didier; Cheikh, Nawel; Liao, Liang; Bar, Nathalie; Lohier, Jean-Francois; Sopkova, Jana; Choukchou-Braham, Noureddine; Mostefa-Kara, Bachir
Tetrahedron, 2012 , vol. 68, # 24 p. 4906 - 4918
反应条件
1: 46 percent / LiOH*H2O / methanol; H2O
2: 74 percent / O2; CuCl; Na2HPO4 / PdCl2 / 1,2-dimethoxy-ethane / Heating
View Scheme
参考文献
Reiter, Maud; Turner, Hazel; Mills-Webb, Rebecca; Gouverneur, Veronique
Journal of Organic Chemistry, 2005 , vol. 70, # 21 p. 8478 - 8485
反应条件
toluene-4-sulfonic acid in xylene
Heating;
参考文献
Gelas, Jacques; Teppaz-Misson, Marc
Canadian Journal of Chemistry, 1983 , vol. 61, p. 1487 - 1493
反应条件
1: 91 percent / triethylamine / dimethylformamide / 24 h / Ambient temperature
2: 1.) LDA / 1.) THF, -78 deg C, 50 min, 2.) room temperature, 30 min
View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Jerris, Paula J.; Scarborough, Robert M.; Wovkulich, Peter M.
Journal of the American Chemical Society, 1981 , vol. 103, # 6 p. 1501 - 1513
反应条件
1: 91 percent / triethylamine / dimethylformamide / 24 h / Ambient temperature
2: 1.) LDA / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C, 5 min
3: 60 percent / CrO3, pyridine / CH2Cl2 / 0.33 h / Ambient temperature
4: 60 percent / 5percent HCl / H2O; tetrahydrofuran / 4.5 h / Ambient temperature
View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Jerris, Paula J.; Scarborough, Robert M.; Wovkulich, Peter M.
Journal of the American Chemical Society, 1981 , vol. 103, # 6 p. 1501 - 1513
反应条件
1: 91 percent / triethylamine / dimethylformamide / 24 h / Ambient temperature
2: 1.) LDA / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C, 5 min
3: 90 percent / CrO3, pyridine / CH2Cl2 / 0.33 h / Ambient temperature
4: 1.) 5percent HCl, 2.) glacial acetic acid / 1.) 50percent aq. THF, room temperature, 4 h, 2.) room temperature, 18 h
View Scheme
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Jerris, Paula J.; Scarborough, Robert M.; Wovkulich, Peter M.
Journal of the American Chemical Society, 1981 , vol. 103, # 6 p. 1501 - 1513
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: tetrahydrofuran; hexane / -78 °C
2.1: 10.6 g / CeCl3*7H2O; NaI / acetonitrile / 3 h / Heating
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Kelso, Michael; Gomez-Bengoa, Enrique; Garcia, Jesus M.
Journal of the American Chemical Society, 2004 , vol. 126, # 30 p. 9188 - 9189
反应条件
1: 95 percent / Br2 / methanol / 24 h / 23 °C
2: KOAc / 4 h / 95 °C
View Scheme
参考文献
Gauthier Jr., Donald R.; Limanto, John; Devine, Paul N.; Desmond, Richard A.; Szumigala Jr., Ronald H.; Foster, Bruce S.; Volante
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5938 - 5945
