α,α-二苯基-4-哌啶甲醇合成路线 （共 34 条）
反应条件
1: 85 percent / Ra-Ni / various solvent(s) / 2 h / Heating 2: 70 percent / K2CO3 / CH2Cl2 / Ambient temperature 3: 75 percent / 50percent KOH / ethanol / 24 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 32, # 4 p. 475 - 476
反应条件
1: sodium tetrahydroborate / methanol / 4 h / 20 °C 2: cyclohexanol / 2 h / Reflux 3: potassium carbonate / chloroform / 20 °C 4: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions View Scheme
参考文献
Medicinal Chemistry Research, , vol. 19, # 3 p. 220 - 235
反应条件
1: tetrahydrofuran / 20 °C / Inert atmosphere 2: acetone / 20 °C 3: sodium tetrahydroborate / methanol / 4 h / 20 °C 4: cyclohexanol / 2 h / Reflux 5: potassium carbonate / chloroform / 20 °C 6: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions View Scheme
参考文献
Medicinal Chemistry Research, , vol. 19, # 3 p. 220 - 235
反应条件
1: tetrahydrofuran / 20 °C / Inert atmosphere 2: acetone / 20 °C 3: sodium tetrahydroborate / methanol / 4 h / 20 °C 4: cyclohexanol / 2 h / Reflux 5: potassium carbonate / chloroform / 20 °C 6: ethanol / 24 h / Reflux; Inert atmosphere; Alkaline conditions View Scheme
参考文献
Medicinal Chemistry Research, , vol. 19, # 3 p. 220 - 235
反应条件
1: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 2: 93 percent / H2O; acetic acid / 105 °C View Scheme
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
trifluoroacetic acid in dichloromethane 7 h; Inert atmosphere;
参考文献
Long, Jonathan Z.; Jin, Xin; Adibekian, Alexander; Li, Weiwei; Cravatt, Benjamin F.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 4 p. 1830 - 1842
反应条件
hydrogen; [rhodium(I)(carbonyl)2(acetylacetonate)]; 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-dibenzo [d,f][1,3,2]-dioxaphosphepine in tetrahydrofuran T=75°C; P=20702.1 Torr; 18 h;
参考文献
UNION CARBIDE CHEMICALS and PLASTICS TECHNOLOGY CORPORATION
Patent: WO2005/77884 A2, 2005 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: 75 percent / K2CO3 / butan-2-one / Heating 2: 96 percent / NaBH4 / methanol View Scheme
参考文献
Carr; Meyer
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 9 A p. 1157 - 1159
反应条件
sodium tetrahydroborate in trifluoroacetic acid
参考文献
Mittapalli, Gopi Kumar; Vellucci, Danielle; Yang, Jun; Toussaint, Marion; Brothers, Shaun P.; Wahlestedt, Claes; Roberts, Edward
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3916 - 3920
反应条件
1.1: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 2.1: 93 percent / H2O; acetic acid / 105 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 25 °C 3.2: t-BuLi / tetrahydrofuran / 0.92 h / -72 °C 3.3: 60 percent / tetrahydrofuran / 2.5 h / -72 °C View Scheme
参考文献
Sepracor Inc.
Patent: US5925761 A1, 1999 ;
