2,3-二氢苯并呋喃-5-磺酰氯合成路线 （共 4 条）
反应条件
1: With sulfur trioxide-N,N-dimethylformamide complex in 1,2-dichloro-ethane T=85°C; 1 h; 2: With thionyl chloride in 1,2-dichloro-ethane T=20 - 75°C; 1 h;
参考文献
SEQUOIA PHARMACEUTICALS, INC.
Patent: US2008/227744 A1, 2008 ;
Location in patent: Page/Page column 12-13 ;
US 20080227744 A1
反应条件
thionyl chloride in water
参考文献
Eli Lilly and Company
Patent: US5387681 A1, 1995 ;
参考文献
BIOVITRUM AB
Patent: WO2006/62481 A1, 2006 ;
Location in patent: Page/Page column 28 ;
WO 2006/062481 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene
T=80°C; 1 h; Product distribution / selectivity;
参考文献
SEQUOIA PHARMACEUTICALS, INC.
Patent: US2008/227744 A1, 2008 ;
Location in patent: Page/Page column 13 ;
US 20080227744 A1
