5-溴-3-甲氧基-2-甲基吡啶合成路线 (共 1 条)
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; toluene Cooling with iceReflux; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water; toluene
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter
Patent: WO2010/135014 A1, 2010 ;
Location in patent: Page/Page column 53-55 ;
WO 2010/135014 A1