2,6-二氮杂螺[3.3]庚烷-2,6-二羧酸二叔丁酯合成路线 （共 2 条）
反应条件
1: 2,2-bis-bromomethyl-propanediyldiamine; dihydrobromide With sodium hydroxide in water T=95 - 100°C; 2: di-tert-butyl dicarbonate With sodium carbonate in tetrahydrofuran; water T=20°C; 16 h;
参考文献
MERCK FROSST CANADA LTD.; LACHANCE, Nicolas; LEGER, Serge; OBALLA, Renata, M.; POWELL, David; TRANMER, Geoffrey, K.; MARTINS, Evelyn; GAREAU, Yves
Patent: WO2010/108268 A1, 2010 ;
Location in patent: Page/Page column 68-69 ;
WO 2010/108268 A1
反应条件
1: di-tert-butyl 2,6-diazaspiro[3.3]heptane-2,6-dicarboxylate With methanol; acetyl chloride T=20°C; 20 h; Inert atmosphere; 2: With potassium hydroxide in methanol T=30°C; 3: oxalic acid in diethyl ether T=20°C; 1 h;
参考文献
MERCK FROSST CANADA LTD.; LACHANCE, Nicolas; LEGER, Serge; OBALLA, Renata, M.; POWELL, David; TRANMER, Geoffrey, K.; MARTINS, Evelyn; GAREAU, Yves
Patent: WO2010/108268 A1, 2010 ;
Location in patent: Page/Page column 69 ;
WO 2010/108268 A1
