4-氨基-5-溴-7-(2-羟基乙氧基甲基)吡咯并(2,3-d)嘧啶合成路线 （共 6 条）
反应条件
ammonia in methanol T=125°C; 10 h;
参考文献
Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2086 - 2092
反应条件
in methanol; chloroform
参考文献
The Regents of the University of Michigan
Patent: US4927830 A1, 1990 ;
反应条件
1: 40.21 percent / 1.) sodium hydride / dimethylformamide / 1.) 0 deg C to 5 deg C, 2.) room temperature, 3 h 2: 50 percent / N-bromosuccinimide / CH2Cl2 / 20 h / Ambient temperature 3: 38.02 percent / ammonia / methanol / 20 h / Ambient temperature 4: 31.25 percent / ammonia / methanol / 10 h / 125 °C View Scheme
参考文献
Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2086 - 2092
反应条件
1: 48 percent / 1.) sodium hydride / dimethylformamide / 2.) room temperature, 45 min 2: 38.02 percent / ammonia / methanol / 20 h / Ambient temperature 3: 31.25 percent / ammonia / methanol / 10 h / 125 °C View Scheme
参考文献
Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2086 - 2092
反应条件
1: 50 percent / N-bromosuccinimide / CH2Cl2 / 20 h / Ambient temperature 2: 38.02 percent / ammonia / methanol / 20 h / Ambient temperature 3: 31.25 percent / ammonia / methanol / 10 h / 125 °C View Scheme
参考文献
Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2086 - 2092
反应条件
1: 38.02 percent / ammonia / methanol / 20 h / Ambient temperature 2: 31.25 percent / ammonia / methanol / 10 h / 125 °C View Scheme
参考文献
Pudlo, Jeffrey S.; Saxena, Naveen K.; Nassiri, M. Reza; Turk, Steven R.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2086 - 2092
