methanol; sodium tetrahydroborate T=20°C; 18 h; Product distribution / selectivity;

1.1: sulfuric acid; copper; copper(II) sulfate / water / 2 h / Reflux 1.2: 80 - 90 °C 2.1: Candida tenuis AKR2B5 xylose reductase [E.(1)C11175]; water; Reduced nicotinamide-adenine dinucleotide / ethanol / 25 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction View Scheme