5-[4-[[[(9H-芴-9-基甲氧基)羰基]氨基]甲基]-3,5-二甲氧基苯氧基]戊酸合成路线 （共 12 条）
反应条件
1: 1.) molecular sieves 3A, 2.) NaBH3CN / 1.) MeOH, reflux, 6 h, 2.) 2 h 2: 70 percent / ammonium formate, H2 / 10percent Pd/C / ethanol / 50 h / 25 °C 3: 1.) 2N aq. NaOH / 1.) dioxane, 25 deg C, 2 h, 2.) dioxane, 25 deg C, 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 18 p. 4993 - 4996
反应条件
1: 1.) KOtBu / 1.) DMF, 25 deg C, 2.) 110 deg C, 5h 2: 4N aq. NaOH / methanol / 1 h / 25 °C 3: 95 percent / NH2OH, Na2CO3 / H2O / 2 h 4: 96 percent / H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr 5: aq. Na2CO3 / dioxane / 3 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
反应条件
1: 1.) KOtBu / 1.) DMF, 25 deg C, 2.) 110 deg C, 5h 2: 4N aq. NaOH / methanol / 1 h / 25 °C 3: 95 percent / NH2OH, Na2CO3 / H2O / 2 h 4: 96 percent / H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr 5: aq. Na2CO3 / dioxane / 3 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
反应条件
1: 95 percent / NH2OH, Na2CO3 / H2O / 2 h 2: 96 percent / H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr 3: aq. Na2CO3 / dioxane / 3 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
反应条件
1: 96 percent / H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr 2: aq. Na2CO3 / dioxane / 3 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
反应条件
1: H2 / 10percent Pd/C / aq. acetic acid / 2 h / 25 °C / 2280 Torr 2: 1.) 2N aq. NaOH / 1.) dioxane, 1.5h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
反应条件
1: 70 percent / ammonium formate, H2 / 10percent Pd/C / ethanol / 50 h / 25 °C 2: 1.) 2N aq. NaOH / 1.) dioxane, 25 deg C, 2 h, 2.) dioxane, 25 deg C, 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 18 p. 4993 - 4996
反应条件
sodium carbonate in 1,4-dioxane T=25°C; 3 h; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
反应条件
sodium hydroxide in 1,4-dioxane; methanol T=25°C; 4 h; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 58, # 18 p. 4993 - 4996
反应条件
sodium carbonate in 1,4-dioxane T=25°C; 3 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 12 p. 3730 - 3743
