3,3-二甲氧基环丁烷-1,1-二羧酸二异丙酯合成路线 （共 4 条）
反应条件
1: malonic acid diisopropyl ester With sodium hydride in N,N-dimethyl-formamide T=70°C; 2: 1,3-Dibromoacetone Dimethyl Ketal in N,N-dimethyl-formamide T=140°C; 48 h;
参考文献
INCYTE CORPORATION
Patent: US2009/233903 A1, 2009 ;
Location in patent: Page/Page column 46 ;
US 20090233903 A1
反应条件
1: malonic acid diisopropyl ester With sodium hydride in DMF (N,N-dimethyl-formamide) T=70°C; 2: 1,3-Dibromoacetone Dimethyl Ketal T=140°C; 48 h;
参考文献
MERCK and CO. INC.
Patent: WO2004/82682 A1, 2004 ;
Location in patent: Page 35 ;
WO 2004/082682 A1
反应条件
sodium hydride 1.) DMF, 2.) 130 deg C, 40 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 53, # 16 p. 3841 - 3843
反应条件
hydrogenchloride 60 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 53, # 16 p. 3841 - 3843
