乙基-N-(2-甲基-3-硝基苯基)亚胺代甲酸酯合成路线 （共 11 条）
反应条件
toluene-4-sulfonic acid T=120°C; 1 h;
参考文献
Bergman, Jan; Sand, Peter
Tetrahedron, 1990 , vol. 46, # 17 p. 6085 - 6112
反应条件
potassium ethanolate; oxalic acid diethyl ester in N,N-dimethyl-formamide T=30 - 40°C; 2.5 h;
参考文献
Kato, Keisuke; Ono, Machiko; Akita, Hiroyuki
Tetrahedron Letters, 1997 , vol. 38, # 10 p. 1805 - 1808
反应条件
potassium ethanolate in diethyl ether; ethanol Heating; Title compound not separated from byproducts;
参考文献
Melhado, L. Lee; Brodsky, Jeffrey L.
Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3852 - 3855
反应条件
potassium ethanolate in N,N-dimethyl-formamide Heating;
参考文献
Bergman, Jan; Sand, Peter
Tetrahedron Letters, 1984 , vol. 25, # 18 p. 1957 - 1960
反应条件
1.1: diethyl oxalate; KOEt / dimethylsulfoxide; dimethylformamide / 24 h / 40 °C 2.1: KOH / acetone / 0 °C 2.2: 85.14 percent / acetone / 2 h / 20 °C View Scheme
参考文献
Ferlin, Maria Grazia; Chiarelotto, Gianfranco; Gasparotto, Venusia; Dalla Via, Lisa; Pezzi, Vincenzo; Barzon, Luisa; Palu, Giorgio; Castagliuolo, Ignazio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3417 - 3427
反应条件
1.1: diethyl oxalate; KOEt / dimethylsulfoxide; dimethylformamide / 24 h / 40 °C 2.1: KOH / acetone / 0 °C 2.2: 85.14 percent / acetone / 2 h / 20 °C 3.1: 60.6 percent / TiCl3; aq. HCl; AcOH / 2 h / 20 °C View Scheme
参考文献
Ferlin, Maria Grazia; Chiarelotto, Gianfranco; Gasparotto, Venusia; Dalla Via, Lisa; Pezzi, Vincenzo; Barzon, Luisa; Palu, Giorgio; Castagliuolo, Ignazio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3417 - 3427
反应条件
1: 77 percent / (COOEt)2, KOEt 2: 93 percent / NaH 3: 73 percent / H2 / 20percent Pd(OH)2-C 4: 1.) NaNO2, hydrogen chloride, 2.) KI 5: 99 percent / NaOMe / methanol View Scheme
参考文献
Kato, Keisuke; Ono, Machiko; Akita, Hiroyuki
Tetrahedron Letters, 1997 , vol. 38, # 10 p. 1805 - 1808
反应条件
1: 77 percent / potassium ethoxide, diethyl oxalate / dimethylformamide / 2.5 h / 30 - 40 °C 2: 92 percent / acetonitrile / 2 h / Heating 3: 85 percent / potassium hydroxide / ethanol / Heating View Scheme
参考文献
Bergman, Jan; Sand, Peter
Tetrahedron, 1990 , vol. 46, # 17 p. 6085 - 6112
反应条件
1: EtOK, (COOEt)2 / dimethylsulfoxide; dimethylformamide / 2 h / Ambient temperature
2: 24 percent / acetonitrile
View Scheme
参考文献
Melhado, L. Lee; Brodsky, Jeffrey L.
Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3852 - 3855
反应条件
1: 1.46 g / EtOK / ethanol; diethyl ether / 34 h / Heating
2: 84 percent / HCl / ethanol / 3 h / 60 °C
3: 1.) Raney nickel, 2.) Raney nickel, H2 / 1.) EtOH, 35 deg C, 24 h, 2.) RT, 40 psi, 1 h
4: 1.) NaNO2, 80percent HOAc, 2.) NaN3 / 0 deg C
5: 79 percent / 1 M NaOH / dioxane / 5 h / Ambient temperature
View Scheme
参考文献
Melhado, L. Lee; Brodsky, Jeffrey L.
Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3852 - 3855
