water in chloroform 2 h; Reflux;

in butanone 24 h; Heating;

1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: dichloromethane / 1.67 h / -30 - 20 °C / |Inert atmosphere 2.2: 3.5 h / 20 °C / |Darkness; |Inert atmosphere 3.1: water / chloroform / 2 h / |Reflux View Scheme

1.1: dichloromethane / 1.67 h / -30 - 20 °C / |Inert atmosphere 1.2: 3.5 h / 20 °C / |Darkness; |Inert atmosphere 2.1: water / chloroform / 2 h / |Reflux View Scheme

1.1: dichloromethane / 1.67 h / -30 - 20 °C / |Inert atmosphere 1.2: 3.5 h / 20 °C / |Darkness; |Inert atmosphere 2.1: water / chloroform / 2 h / |Reflux View Scheme

in dichloromethane 17 h; Ambient temperature;

silica gel in methanol; dichloromethane Yield given;