1-环丙基吡唑-4-硼酸片呐醇酯合成路线 （共 3 条）
反应条件
1: 1-cyclopropyl-4-iodo-1H-pyrazole With isopropylmagnesium chloride in tetrahydrofuran T=0°C; 0.75 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 84 ;
US 20110230462 A1
反应条件
sodium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide T=150°C; 1 h; Inert atmosphereSealed microwave vial;
参考文献
WO2010/141273 A1, ;
Page/Page column 53 ;
反应条件
1: 4-bromo-1-cyclopropyl-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=-70°C; 3 h;
参考文献
WO2014/32498 A1, ;
Page/Page column 18-19 ;
