4-溴-1-环丙基-1H-吡唑合成路线 （共 4 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=180°C; 1.5 h; Microwave irradiation;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng
Patent: WO2014/32498 A1, 2014 ;
Location in patent: Page/Page column 14 ;
反应条件
bromine in chloroform T=20°C; 1 h;
参考文献
WO2010/141273 A1, ;
Page/Page column 53 ;
反应条件
sodium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide T=150°C; 1 h; Inert atmosphereSealed microwave vial;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEMIEUX, Rene, Marc; BRUNETTE, Steven, Richard; HORAN, Joshua, Courtney; KOWALSKI, Jennifer, A.; LAWLOR, Michael, David; MCKIBBEN, Bryan; MILLER, Craig, Andrew; BARBOSA, Antonio, J.M.
Patent: WO2010/141273 A1, 2010 ;
Location in patent: Page/Page column 53 ;
反应条件
1: 4-bromo-1-cyclopropyl-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=-70°C; 3 h;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng
Patent: WO2014/32498 A1, 2014 ;
Location in patent: Page/Page column 18-19 ;
